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. 2024 Feb 20:7:e54217.
doi: 10.2196/54217.

Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis

Sofia Eva Olsson  1 , Bhavana Sreepad #  1 , Trevor Lee  1 , Manal Fasih  1 , Arman Fijany  1
Affiliations

Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis

Sofia Eva Olsson et al. JMIR Dermatol. .

Abstract

Background: Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin.

Objective: This study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine.

Methods: We analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide-related terms. We compared the internet search trends for "Botox" during this period to "Argireline."

Results: The terms "Argireline" and "Botox in a Bottle" both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, "Argireline" was less searched than "Botox," which had a stable, up-trending search volume over the past decade.

Conclusions: The increasing interest in acetyl hexapeptide-8 may be due to its cost-effectiveness and use as a botulinum neurotoxin alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care.

Keywords: Argireline; BoNT; acetyl-hexapeptide-8; anti-aging; anti-wrinkle; botox; botulinum neurotoxin; cosmetic; cosmetic dermatology; dermatologist; dermatology; injectable neurotoxin; neurotoxin; skin specialist; topical; topical agent.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
Relative search volume of acetyl hexapeptide–related terms on Google from January 1, 2013, to January 1, 2023.
Figure 2
Figure 2
Comparison of relative Google search volume for search terms “Argireline” and “Botox” from January 1, 2013, to January 1, 2023.
See this image and copyright information in PMC

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