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. 2024 Feb 20;22(1):76.
doi: 10.1186/s12916-024-03287-1.

Efficacy of interventions targeted at physician prescribers of opioids for chronic non-cancer pain: an overview of systematic reviews

Katya Peri  1   2 , Lucy Honeycutt  1 , Erica Wennberg  1   3 , Sarah B Windle  1   4 , Kristian B Filion  1   4   2 , Genevieve Gore  5 , Irina Kudrina  6 , Elena Paraskevopoulos  7 , Areesha Moiz  1 , Marc O Martel  8 , Mark J Eisenberg  9   10   11
Affiliations

Efficacy of interventions targeted at physician prescribers of opioids for chronic non-cancer pain: an overview of systematic reviews

Katya Peri et al. BMC Med. .

Abstract

Background: To combat the opioid crisis, interventions targeting the opioid prescribing behaviour of physicians involved in the management of patients with chronic non-cancer pain (CNCP) have been introduced in clinical settings. An integrative synthesis of systematic review evidence is required to better understand the effects of these interventions. Our objective was to synthesize the systematic review evidence on the effect of interventions targeting the behaviours of physician opioid prescribers for CNCP among adults on patient and population health and prescriber behaviour.

Methods: We searched MEDLINE, Embase, and PsycInfo via Ovid; the Cochrane Database of Systematic Reviews; and Epistemonikos. We included systematic reviews that evaluate any type of intervention aimed at impacting opioid prescriber behaviour for adult CNCP in an outpatient setting.

Results: We identified three full texts for our review that contained 68 unique primary studies. The main interventions we evaluated were structured prescriber education (one review) and prescription drug monitoring programmes (PDMPs) (two reviews). Due to the paucity of data available, we could not determine with certainty that education interventions improved outcomes in deprescribing. There is some evidence that PDMPs decrease the number of adverse opioid-related events, increase communication among healthcare workers and patients, modify healthcare practitioners' approach towards their opioid prescribed patients, and offer more chances for education and counselling.

Conclusions: Our overview explores the possibility of PDMPs as an opioid deprescribing intervention and highlights the need for more high-quality primary research on this topic.

Keywords: Opioid; Overview; Prescribing; Systematic review; Umbrella review.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Harper S, Riddell CA, King NB. Declining Life Expectancy in the United States: Missing the Trees for the Forest. Annu Rev Public Health. 2021;42:381–403. - PubMed
    1. Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med. 2011;1:a006841. - PMC - PubMed
    1. DeWeerdt S. Tracing the US opioid crisis to its roots. Nature. 2019;573:S10–S12. - PubMed
    1. The L. A time of crisis for the opioid epidemic in the USA. Lancet. 2021;398:277. - PMC - PubMed
    1. Volkow ND, Jones EB, Einstein EB, Wargo EM. Prevention and Treatment of Opioid Misuse and Addiction: A Review. JAMA Psychiat. 2019;76:208–216. - PubMed

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