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. 2024 Jan 31;69(4):E144-E150.
doi: 10.24546/0100486232.

Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal

Yasuyuki Kajimoto  1 , Hirotaka Shinomiya  1 , Natsumi Uehara  1 , Masanori Teshima  1 , Takeshi Fujita  1 , Akinobu Kakigi  1 , Yoshinori Imamura  2 , Naomi Kiyota  2 , Daisuke Miyawaki  2 , Ryohei Sasaki  2 , Hidehito Kimura  3 , Ken-Ichi Nibu  1
Affiliations

Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal

Yasuyuki Kajimoto et al. Kobe J Med Sci. .

Abstract

The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.

Keywords: EGFR; Ear cancer; Kobe classification; Temporal bone; p16.

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Figures

Fig. 1
Fig. 1
Expression of EGFR and p16 a. positive expression of EGFR b. strongly positive expression of p16 c. weakly positive expression of p16
Fig. 2
Fig. 2
Overall survival of all the patients according to T classification
Fig. 3
Fig. 3
Overall survival of surgically treated patients according to T classification
Fig. 4
Fig. 4
Overall survival of surgically treated patients according to EGFR expression
Fig. 5
Fig. 5
Overall survival of surgically treated patients according to p16 expression
Fig. 6
Fig. 6
Overall survival of all the patients with T3/T4a EACSCC a: strongly positive vs. weakly positive vs. negative b: positive (strongly + weakly) vs. negative
See this image and copyright information in PMC

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