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. 1986:97:43-52.

A rational scientific basis for subclassification of antiarrhythmic drugs

D C Harrison

A rational scientific basis for subclassification of antiarrhythmic drugs

D C Harrison. Trans Am Clin Climatol Assoc. 1986.

Abstract

The subclassification of Vaughan Williams Class I agents into IA, IB, and IC groups on empiric and clinical grounds has recently been given a cellular electrophysiologic scientific basis. Based on the kinetics of association and dissociation of the drugs with sodium channels, 3 distinct subgroups can be defined. These observations help to explain the clinical utility of the algorithms to use the agents in patients and provide a reference for discussing the new drugs with antiarrhythmic properties being discovered.

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