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Review
. 2024 Feb 6:15:1331508.
doi: 10.3389/fmicb.2024.1331508. eCollection 2024.

Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Thanh Quang Nguyen  1 , Bo Eun Heo  1 , Seunghyeon Jeon  1 , Anwesha Ash  1 , Heehyun Lee  1 , Cheol Moon  2 , Jichan Jang  1
Affiliations
Review

Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Thanh Quang Nguyen et al. Front Microbiol. .

Abstract

Mycobacterium abscessus, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of M. abscessus is crucial for effective treatment. This review highlights the mechanisms employed by M. abscessus to sustain antibiotic resistance, encompassing not only conventional drugs but also newly discovered drug candidates. This comprehensive analysis aims to identify novel entities capable of overcoming the notorious resistance exhibited by M. abscessus, providing insights for the development of more effective therapeutic interventions.

Keywords: Mycobacterium abscessus; drug resistance; efflux pump; intrinsic-extrinsic drug resistance; mycobacterium drug efficacy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Drug resistance mechanisms and related genes in Mab.
Figure 2
Figure 2
Schematic representation of mycobacterial cell envelope based on the figure of Gutiérrez et al.
See this image and copyright information in PMC

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