Comparative Study
doi: 10.1016/0014-5793(85)80953-4.
Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat
- PMID: 3838518
- DOI: 10.1016/0014-5793(85)80953-4
Item in Clipboard
Comparative Study
Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat
FEBS Lett.
.
Free article
Abstract
The nucleotide sequence analysis of cloned cDNA for VIP precursor from rat cerebral cortex reveals that the precursor contains both rat VIP and PHI-27. The deduced primary structure of rat VIP is identical with human VIP. The amino acid sequence of rat PHI-27 differs by 4 amino acids from human PHM-27. When each VIP precursor is divided functionally into 6 domains, the amino acid sequence homology between rat and human precursors ranges from 69 to 100%. In contrast, any domain exhibits an essentially equal degree of nucleotide sequence homology.
Similar articles
-
In situ hybridization reveals VIP precursor mRNA-containing neurons in monkey and rat neocortex.Brain Res Mol Brain Res. 1991 Jan;9(1-2):169-74. doi: 10.1016/0169-328x(91)90145-n. Brain Res Mol Brain Res. 1991. PMID: 1850073
-
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27.Nature. 1983 Aug 11-17;304(5926):547-9. doi: 10.1038/304547a0. Nature. 1983. PMID: 6571696
-
Structure and expression of the gene encoding the vasoactive intestinal peptide precursor.Proc Natl Acad Sci U S A. 1987 Jan;84(2):605-9. doi: 10.1073/pnas.84.2.605. Proc Natl Acad Sci U S A. 1987. PMID: 3025882 Free PMC article.
-
[Elucidation of biosynthetic process and regulation mechanism of bioactive peptides and their receptors].Yakugaku Zasshi. 1992 Jul;112(7):419-31. doi: 10.1248/yakushi1947.112.7_419. Yakugaku Zasshi. 1992. PMID: 1432595 Review. Japanese.
-
Biosynthesis and Function of VIP and Oxytocin: Mechanisms of C-terminal Amidation, Oxytocin Secretion and Transport.Endocrinology. 2023 Aug 1;164(9):bqad121. doi: 10.1210/endocr/bqad121. Endocrinology. 2023. PMID: 37548257 Review.
Cited by
-
Location of PHM/VIP mRNA in human gastrointestinal tract detected by in situ hybridization.Cell Tissue Res. 1994 May;276(2):229-38. doi: 10.1007/BF00306108. Cell Tissue Res. 1994. PMID: 8020060
-
Chronic alcohol consumption and withdrawal do not induce cell death in the suprachiasmatic nucleus, but lead to irreversible depression of peptide immunoreactivity and mRNA levels.J Neurosci. 1997 Feb 15;17(4):1302-19. doi: 10.1523/JNEUROSCI.17-04-01302.1997. J Neurosci. 1997. PMID: 9006974 Free PMC article.
-
Marked increase in nitric oxide synthase mRNA in rat dorsal root ganglia after peripheral axotomy: in situ hybridization and functional studies.Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11617-21. doi: 10.1073/pnas.89.23.11617. Proc Natl Acad Sci U S A. 1992. PMID: 1280832 Free PMC article.
-
A diurnal variation of vasoactive intestinal peptide (VIP) mRNA under a daily light-dark cycle in the rat suprachiasmatic nucleus.Histochemistry. 1991;95(5):525-8. doi: 10.1007/BF00315750. Histochemistry. 1991. PMID: 1869450
-
The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.Front Neuroendocrinol. 2017 Jan;44:35-82. doi: 10.1016/j.yfrne.2016.11.003. Epub 2016 Nov 25. Front Neuroendocrinol. 2017. PMID: 27894927 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
