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. 2024;24(10):745-754.
doi: 10.2174/0118715206282983240215050314.

Anticancer Activity of Sargassum fluitans Extracts in Different Cancer Cells

José Arnold González-Garrido  1 , Javier Alejandro Gómez-García  1 , Oswaldo Ignacio Hernández-Abreu  1 , Ivonne María Olivares-Corichi  2 , Fernando Pereyra-Vergara  2 , José Rubén García-Sánchez  2
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Anticancer Activity of Sargassum fluitans Extracts in Different Cancer Cells

José Arnold González-Garrido et al. Anticancer Agents Med Chem. 2024.

Abstract

Background: The arrival of large quantities of Sargassum in the Mexican Caribbean Sea has generated major environmental, health and economic problems. Although Sargassum has been used in the generation of some commercial products, few studies have described its possible applications as a source of compounds with anticancer activity.

Objective: This study aimed to evaluate the antiproliferative effects of different Sargassum extracts on various cancer cell lines. Furthermore, LC/QTOF-MS was used to identify the compounds related to the antiproliferative effect.

Methods: First, determination of the seaweed was performed, and dichloromethane, chloroform and methanol extracts were obtained. The extracts were evaluated for their antiproliferative effects by MTT in breast (MDAMB- 231 and MCF-7), prostate (DU-145), lung (A549) and cervical (SiHa) cancer cell lines. Finally, LC/QTOFMS identified the compounds related to the antiproliferative effect.

Results: The authentication showed Sargassum fluitans as the predominant species. The extracts of dichloromethane and chloroform showed an antiproliferative effect. Interestingly, the fractionation of the chloroform extract showed two fractions (FC1 and FC2) with antiproliferative activity in MDA-MB-231, SiHa and A549 cancer cell lines. On the other hand, three fractions of dichloromethane extract (FD1, FD4 and FD5) also showed antiproliferative effects in the MDA-MB-231, MCF-7, SiHa and DU-145 cancer cell lines. Furthermore, LC/QTOF-MS revealed the presence of eight major compounds in FC2. Three compounds with evidence of anticancer activity were identified (D-linalool-3-glucoside, (3R,4S,6E,10Z)-3,4,7,11-tetramethyl-6,10-tridecadienal and alpha-tocotrienol).

Conclusion: These findings showed that Sargassum fluitans extracts are a possible source of therapeutic agents against cancer and could act as scaffolds for new drug discovery.

Keywords: Antiproliferation; LC/QTOF-MS; Sargassum fluitans; antiproliferative effect.; cancer; caribbean sea.

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References

    1. Jonathan M.K.; Kelly C.; Frances E.D.; Weijia F.; Brian L.G.; Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: A systematic analysis for the global burden of disease study 2019. JAMA Oncol 2022,8(3),420-444 - DOI
    1. D’Alterio C.; Scala S.; Sozzi G.; Roz L.; Bertolini G.; Paradoxical effects of chemotherapy on tumor relapse and metastasis promotion. Semin Cancer Biol 2020,60,351-361 - DOI - PubMed
    1. Sung H.; Ferlay J.; Siegel R.L.; Laversanne M.; Soerjomataram I.; Jemal A.; Bray F.; Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021,71(3),209-249 - DOI - PubMed
    1. Dutt R.; Garg V.; Khatri N.; Madan A.K.; Phytochemicals in anticancer drug development. Anticancer Agents Med Chem 2019,19(2),172-183 - DOI - PubMed
    1. Roleira F.M.F.; Varela C.L.; Costa S.C.; Tavares-da-Silva E.J.; Phenolic derivatives from medicinal herbs and plant extracts: anticancer effects and synthetic approaches to modulate biological activity. Stu Nat Prod Chem 2018,57,115-156 - DOI

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