Update on olfactory neuroblastoma

Fernando Lopez¹, Abbas Agaimy², Alessandro Franchi³, Carlos Suárez⁴, Vincent Vander Poorten⁵, Antti A Mäkitie⁶, Akihiro Homma⁷, Avraham Eisbruch⁸, Kerry D Olsen⁹, Nabil F Saba¹⁰, Sandra Nuyts¹¹, Carl Snyderman¹², Jonathan J Beitler¹³, June Corry¹⁴, Ehab Hanna¹⁵, Henrik Hellquist^{16

17}, Alessandra Rinaldo¹⁸, Alfio Ferlito¹⁹

Affiliations

¹ Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Avenida de Roma, S/N, 33011, Oviedo, Asturias, Spain. flopez_1981@yahoo.es.
² Institut Für Pathologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
³ Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126, Pisa, Italy.
⁴ University of Oviedo, Oviedo, Spain.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Department of Oncology, Section of Head and Neck Oncology, KU Leuven, and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
⁶ Department of Otorhinolaryngology - Head and Neck Surgery, Research Program in Systems Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
⁷ Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
⁸ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
⁹ Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN, USA.
¹⁰ Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
¹¹ Department of Radiation Oncology, University Hospitals Leuven, KU Leuven-University of Leuven, 3000, Leuven, Belgium.
¹² Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹³ Radiation Oncology, Knox County Health Clinic, Rockland, ME, USA.
¹⁴ Division of Radiation Oncology, GenesisCare Radiation Oncology, St. Vincent's Hospital, Melbourne, VIC, 3065, Australia.
¹⁵ Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
¹⁶ Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Algarve Biomedical Center Research Institute (ABC-RI), 8005-139, Faro, Portugal.
¹⁷ Department of Cellular Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Lincoln, LN2 5QY, UK.
¹⁸ ENT Unit, Policlinico Città di Udine, Udine, Italy.
¹⁹ Coordinator of International Head and Neck Scientific Group, Padua, Italy.

PMID: 38386106
DOI: 10.1007/s00428-024-03758-z

Review

Update on olfactory neuroblastoma

Fernando Lopez et al. Virchows Arch. 2024 Apr.

. 2024 Apr;484(4):567-585.

doi: 10.1007/s00428-024-03758-z. Epub 2024 Feb 22.

Authors

Affiliations

¹ Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Avenida de Roma, S/N, 33011, Oviedo, Asturias, Spain. flopez_1981@yahoo.es.
² Institut Für Pathologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
³ Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126, Pisa, Italy.
⁴ University of Oviedo, Oviedo, Spain.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Department of Oncology, Section of Head and Neck Oncology, KU Leuven, and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
⁶ Department of Otorhinolaryngology - Head and Neck Surgery, Research Program in Systems Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
⁷ Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
⁸ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
⁹ Department of Otorhinolaryngology, Mayo Clinic, Rochester, MN, USA.
¹⁰ Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
¹¹ Department of Radiation Oncology, University Hospitals Leuven, KU Leuven-University of Leuven, 3000, Leuven, Belgium.
¹² Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹³ Radiation Oncology, Knox County Health Clinic, Rockland, ME, USA.
¹⁴ Division of Radiation Oncology, GenesisCare Radiation Oncology, St. Vincent's Hospital, Melbourne, VIC, 3065, Australia.
¹⁵ Department of Head & Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
¹⁶ Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Algarve Biomedical Center Research Institute (ABC-RI), 8005-139, Faro, Portugal.
¹⁷ Department of Cellular Pathology, Northern Lincolnshire and Goole NHS Foundation Trust, Lincoln, LN2 5QY, UK.
¹⁸ ENT Unit, Policlinico Città di Udine, Udine, Italy.
¹⁹ Coordinator of International Head and Neck Scientific Group, Padua, Italy.

PMID: 38386106
DOI: 10.1007/s00428-024-03758-z

Abstract

Olfactory neuroblastomas are uncommon malignancies that arise from olfactory receptor cells located high in the nasal cavity. Accurate diagnosis plays a crucial role in determining clinical results and guiding treatment decisions. Diagnosis can be a major challenge for pathologists, especially when dealing with tumours with poor differentiation. The discovery of several molecular and immunohistochemical markers would help to overcome classification difficulties. Due to the paucity of large-scale studies, standardisation of diagnosis, treatment and prediction of outcome remains a challenge. Surgical resection by endoscopic techniques with the addition of postoperative irradiation is the treatment of choice. In addition, it is advisable to consider elective neck irradiation to minimise the risk of nodal recurrence. Molecular characterisation will help not only to make more accurate diagnoses but also to identify specific molecular targets that can be used to develop personalised treatment options tailored to each patient. The present review aims to summarise the current state of knowledge on histopathological diagnosis, the molecular biology and management of this disease.

Keywords: Chemotherapy; Diagnosis; Esthesioneuroblastomas; Molecular characterisation; Olfactory neuroblastomas; Outcomes; Radiotherapy; Sinonasal tumours; Staging system; Surgery.

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References

1. Berger L, Luc G, Richard D (1924) L’esthesioneuroepitheliome olfactive. Bull Assoc Etude Cancer 3:410–421
1. Ghaffar S, Salahuddin I (2005) Olfactory neuroblastoma: a case report and review of the literature. Ear Nose Throat J 84:150–152. https://doi.org/10.1177/014556130508400311 - DOI - PubMed
1. Gamrot-Wrzoł M, Sowa P, Lisowska G, Scierski W, Misiołek M (2017) Risk factors of recurrence and malignant transformation of sinonasal inverted papilloma. Biomed Res Int 9195163. https://doi.org/10.1155/2017/9195163
1. Gandhoke CS, Dewan A, Gupta D, Syal SK, Jagetia A, Saran RK (2020) A rare case report of mixed olfactory neuroblastoma: carcinoma with review of literature. Surg Neurol Int 8:1–11. https://doi.org/10.4103/sni.sni_30_17 - DOI
1. McVey GP, Power DG, Aherne NJ, Gibbons D, Carney DN (2009) Post irradiation olfactory neuroblastoma (esthesioneuroblastoma): a case report and up to date review. Acta Oncol 48:937–940. https://doi.org/10.1080/02841860902759709 - DOI - PubMed

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Update on olfactory neuroblastoma

Affiliations

Update on olfactory neuroblastoma

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Abstract

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Medical