Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 22:15910199241233020.
doi: 10.1177/15910199241233020. Online ahead of print.

Ophthalmic artery stenosis on three-dimensional rotational angiography: Interrater agreement, prevalence, and risk factors

William K Diprose  1   2 , Michael T M Wang  3   4 , Joseph Reidy  1 , Alice Ma  1   2 , James Brodie  3   5 , Brendan Steinfort  1   2
Affiliations

Ophthalmic artery stenosis on three-dimensional rotational angiography: Interrater agreement, prevalence, and risk factors

William K Diprose et al. Interv Neuroradiol. .

Abstract

Background: There is emerging interest in ophthalmic artery (OA) stenosis angioplasty for the treatment of age-related macular degeneration. Three-dimensional rotational angiography (3DRA) could be used during conventional angiography to determine the presence and severity of OA stenosis. In patients who had undergone 3DRA of the internal carotid artery, we aimed to assess the interrater agreement, prevalence, and risk factors for OA stenosis.

Methods: Consecutive patients from two centers who had undergone conventional angiography with 3DRA of the internal carotid arteries were enrolled in this study. 3DRAs were independently double read for the presence of OA stenosis, as defined as narrowing of the proximal OA of at least 50% when compared to the more distal "normal" OA. Interrater agreement for the evaluation of OA stenosis was assessed with the Cohen's kappa coefficient. Univariate and multivariable logistic regression were used to identify potential predictors of OA stenosis.

Results: Three hundred and two patients (97 men; mean ± SD 57.6 ± 13.4 years) were included in the analysis. Cohen's kappa coefficient (95% CI) was 0.877 (0.798-0.956). OA stenosis was present in 45 patients (14.9%). Multiple logistic regression demonstrated that female sex (odds ratio [OR] = 2.70, 95% confidence interval [CI] 1.18-6.09, p = 0.02) and smoking (OR = 2.11, 95% CI 1.10-4.06, p = 0.03) were significant risk factors for OA stenosis. Age, hypertension, diabetes, coronary artery disease, and subarachnoid hemorrhage were not associated with OA stenosis.

Conclusion: The evaluation of OA stenosis on 3DRA had excellent interrater agreement. OA stenosis was common and was associated with smoking and female sex.

Keywords: Ophthalmic artery; age-related macular degeneration; three-dimensional rotational angiography.

PubMed Disclaimer

Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Criteria for the diagnosis of ophthalmic artery stenosis. ICA: internal carotid artery; OA: ophthalmic artery.
Figure 2.
Figure 2.
Three-dimensional rotational angiogram demonstrating a normal ophthalmic artery (a), and digital subtraction angiography (b) and three-dimensional rotational angiograms (c and d) demonstrating ophthalmic artery stenosis.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Weinberger J, Bender AN, Yang WC. Amaurosis fugax associated with ophthalmic artery stenosis: clinical simulation of carotid artery disease. Stroke 1980; 11: 290–293. - PubMed
    1. Adams HP, Jr, Putman SF, Corbett JJ, et al. Amaurosis fugax: the results of arteriography in 59 patients. Stroke 1983; 14: 742–744. - PubMed
    1. Braat AE, Hoogland PH, de Vries AC, et al. Amaurosis fugax and stenosis of the ophthalmic artery–a case report. Vasc Surg 2001; 35: 141–143. - PubMed
    1. Shi Y, Zhang Q, Zhou H, et al. Correlations between choriocapillaris and choroidal measurements and the growth of geographic atrophy using swept source OCT imaging. Am J Ophthalmol 2021; 224: 321–331. - PMC - PubMed
    1. Coleman DJ, Silverman RH, Rondeau MJ, et al. Age-related macular degeneration: choroidal ischaemia? Br J Ophthalmol 2013; 97: 1020–1023. - PMC - PubMed

LinkOut - more resources