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. 2024 May;36(5):300-306.
doi: 10.1016/j.clon.2024.02.010. Epub 2024 Feb 15.

Oral Cavity Cancers: Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community

N Patil  1 , N Ma  2 , M Mair  2 , J Nazareth  2 , A Sim  2 , C Reynolds  2 , N Freeman  2 , M Chauhan  2 , L Howells  3 , D Peel  4 , S Ahmad  2 , T Sridhar  2 , H S Walter  5
Affiliations

Oral Cavity Cancers: Ethnic Differences in Radiotherapy Outcomes in a Majority South Asian Leicester Community

N Patil et al. Clin Oncol (R Coll Radiol). 2024 May.

Abstract

Aims: Squamous cell carcinoma oral cavity cancers (SCCOCCs) have a higher reported incidence in South Asian countries. We sought to compare presenting stage and outcome by ethnicity in patients with SCCOCC treated with radical radiotherapy in a single centre in the UK.

Materials and methods: All patients with SCCOCC treated with radical radiotherapy at an oncology department in Leicester (UK) between 2011 and 2017 were identified. Baseline demographic, clinical data and 2-year treatment outcomes were reported.

Results: Of the 109 patients included, 40 were South Asian and 59 were non-South Asian. South Asians had significantly poorer 2-year disease-free survival compared with non-South Asians (54.6% versus 73%, P = 0.01).

Conclusion: Our analysis suggests that South Asians with SCCOCC have poorer outcomes despite a younger age and similar disease characteristics. Environmental, social factors and differing biology of disease may be responsible and further research is required to inform targeted interventions.

Keywords: Deprivation; South Asian; ethnicity; oral cancer; squamous cell carcinoma.

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