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. 2024 Feb 22;23(1):54.
doi: 10.1186/s12944-024-02040-0.

Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population

Sophie Bouhour  1 , Rosalie Plantefève  2 , Virginie Gillet  1 , Armita Abolghasemi  2 , Fatima Zahra Bouchouirab  2 , Andrea A Baccarelli  3 , Larissa Takser  1   4 , Artuela Çaku  5
Affiliations

Establishing non-fasting reference values for plasma lipids levels based on age, sex, and puberty stage in a French-Canadian pediatric population

Sophie Bouhour et al. Lipids Health Dis. .

Abstract

Background: Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is a genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased probability of early cardiovascular disorders. Heterozygous familial hypercholesterolemia (HeFH) is the most common form, affecting approximately 1 in 250 individuals worldwide, with a higher prevalence among the French-Canadian population. Childhood is a critical period for screening risk factors, but the recommendation for non-fasting screening remains controversial due to a lack of specific reference values for this state. This study aims to establish reference values for lipid levels in non-fasting children from Sherbrooke, Quebec, Canada, that will be specific for sex, age, and pubertal stages.

Methods: Blood samples and corresponding anthropometric data were collected from 356 healthy children aged from 6 to 13. They were categorized either into two age groups: Cohort 6-8 and Cohort 9-13, or into pubertal stages. Reference values, specifically the 2.5th, 5th, 10th, 50th, 90th, 95th, and 97.5th percentiles were determined using the CLSI C28-A3 guidelines.

Results: Lipid profiles did not significantly differ between sexes, except for higher levels of high-density lipoprotein (HDL-C) in boys within Cohort 6-8. HDL-C levels significantly increased, while LDL-C and non-HDL-C levels significantly decreased in both sexes with age. Non-fasting age- and pubertal stages-specific reference values were established.

Conclusion: This study established reference intervals for lipid markers in non-fasting state within the pediatric French-Canadian population. These findings could be used in dyslipidemia screening in daily practice.

Keywords: Dyslipidemia; French-Canadian; Lipid profile; Non-fasting state; Pediatric; Reference intervals.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart for selection of study participants
Fig. 2
Fig. 2
Impact of age on lipid levels for girls and boys. HDL-C High-density lipoprotein, LDL-C Low-density lipoprotein, Non-HDL-C Non-High-density lipoprotein, SD Standard Deviation, TC Total Cholesterol, TG Triglycerides
See this image and copyright information in PMC

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