Studies on the interaction of Mycobacterium microti and Mycobacterium lepraemurium with mouse polymorphonuclear leucocytes
- PMID: 383895
- DOI: 10.1099/00221287-112-1-185
Studies on the interaction of Mycobacterium microti and Mycobacterium lepraemurium with mouse polymorphonuclear leucocytes
Abstract
When polymorphonuclear leucocytes (PMN) elicited in mice were infected with Mycobacterium microti or Mycobacterium lepraemurium, phagosome-lysosome fusion occurred with both species. This contrasts with the situation in macrophages where phagosome-lysosome fusion is inhibited by M. microti but not M. lepraemurium. No evidence was found for killing of M. microti or M. lepraemurium when the bacteria were isolated from PMN and their viability tested in cell-free medium or macrophages.
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