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Review
. 2022 Mar 30;10(1):e099.
doi: 10.21142/2523-2754-1001-2022-099. eCollection 2022 Jan-Mar.

[Herpes simplex factors: Literature review]

[Article in Spanish]
Lisette Begazo  1 , Alysson Morante  1 , Carlos Espinoza Montes  1
Affiliations
Review

[Herpes simplex factors: Literature review]

[Article in Spanish]
Lisette Begazo et al. Rev Cient Odontol (Lima). .

Abstract
in English, Spanish

Herpes simplex virus, after the first infection, can remain dormant in the lymph nodes and reactivate at any time due to certain factors and/or stimuli causing effects in the patient. The purpose of this literature review is to update scientific information on the factors that predispose to the reactivation of herpes simplex virus. A comprehensive literature review was conducted in the LILACS, SciELO, PubMed, Scopus and the following keywords were used: herpes simplex, reactivation, latency and risks. A factor is reactivation by immunosuppression due to the intake of immunosuppressants or oncological therapy. Another factor is psychological stress, in which the hormones released act on mediating signs of reactivation. Sun exposure that reactivates the virus in infected neurons and infection in pregnant women can trigger complications in the fetus and delivery.

El virus del herpes simple, después de la primera infección, puede permanecer latente en los ganglios y reactivarse en cualquier momento debido a ciertos factores o estímulos, lo que ocasiona efectos en el paciente. El objetivo de esta revisión de literatura es actualizar la información científica sobre los factores que predisponen la reactivación del virus del herpes simple. Se realizó una revisión bibliográfica exhaustiva en las bases de datos LILACS, SciELO, PubMed y Scopus, mediante las palabras clave “herpes simple”, “reactivación”, “latencia” y “riesgos”. Entre los factores descritos están la reactivación por inmunosupresión debido a la ingesta de inmunosupresores o la terapia oncológica. Otro factor es el estrés psicológico, en el cual las hormonas liberadas actúan sobre señales mediadoras de la reactivación, así como la exposición solar, que reactiva al virus en las neuronas infectadas, y la infección en mujeres gestantes, que puede desencadenar complicaciones en el feto y en el momento del parto.

Keywords: herpes simplex; immunosuppression; virus latency.

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Conflict of interest statement

Conflictos de intereses: Los autores declaran no tener ningún conflicto de intereses

References

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