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Review
. 2024 Jan 27;10(2):102.
doi: 10.3390/gels10020102.

A Systematic Review on Organ-on-a-Chip in PDMS or Hydrogel in Dentistry: An Update of the Literature

Tania Vanessa Pierfelice  1 , Emira D'Amico  1 , Morena Petrini  1 , Mario Romano  1 , Camillo D'Arcangelo  1 , Ludovico Sbordone  2 , Antonio Barone  3   4 , Roberto Plebani  1 , Giovanna Iezzi  1
Affiliations
Review

A Systematic Review on Organ-on-a-Chip in PDMS or Hydrogel in Dentistry: An Update of the Literature

Tania Vanessa Pierfelice et al. Gels. .

Abstract

Organs-on-a-chip (OoCs) are microfluidic devices constituted by PDMS or hydrogel in which different layers of cells are separated by a semipermeable membrane. This technology can set many parameters, like fluid shear stress, chemical concentration gradient, tissue-organ interface, and cell interaction. The use of these devices in medical research permits the investigation of cell patterning, tissue-material interface, and organ-organ interaction, mimicking the complex structures and microenvironment of human and animal bodies. This technology allows us to reconstitute in vitro complex conditions that recapitulate in vivo environments. One of the main advantages of these systems is that they represent a very realistic model that, in many cases, can replace animal experimentation, eliminating costs and related ethical issues. Organ-on-a-chip can also contain bacteria or cancer cells. This technology could be beneficial in dentistry for testing novel antibacterial substances and biomaterials, performing studies on inflammatory disease, or planning preclinical studies. A significant number of publications and reviews have been published on this topic. Still, to our knowledge, they mainly focus on the materials used for fabrication and the different patterns of the chip applied to the experimentations. This review presents the most recent applications of organ-on-a-chip models in dentistry, starting from the reconstituted dental tissues to their clinical applications and future perspectives.

Keywords: microfluidic devices; oral cancer-on-a-chip; oral mucosa-on-a-chip; organ-on-a-chip; salivary glands-on-a-chip.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of tooth and supporting tissues.
Figure 2
Figure 2
Schematic representation of tooth-on a chip models included in this review [15,16,17,21,28,29,30,31,32,33,34,35,36,37,38,39,40,41].
Figure 3
Figure 3
Schematic representation of mucosa-on a chip models included in this review [19,23,47,48,49,50].
Figure 4
Figure 4
Schematic representation of bone-on-a-chip models included in this review [51,52,53,54,55,56].
Figure 5
Figure 5
Schematic representation of cancer-on-a-chip models included in this review [20,60,61,62,63,64,65].
Figure 6
Figure 6
Schematic representation of salivary gland-on-a-chip models included in this review [18,70].
Figure 7
Figure 7
Flow chart of methodologies to obtain the revised original manuscripts.
Figure 8
Figure 8
The topics of the 39 original articles included in the review.
See this image and copyright information in PMC

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