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. 1985 Jul;316(6024):126-31.
doi: 10.1038/316126a0.

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

B P Richardson, G Engel, P Donatsch, P A Stadler

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

B P Richardson et al. Nature. 1985 Jul.

Abstract

We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.

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