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. 2024 Feb 23;19(2):e0297467.
doi: 10.1371/journal.pone.0297467. eCollection 2024.

Formulation and characterization of glipizide solid dosage form with enhanced solubility

Badriyah Shadid Alotaibi  1 , Muhammad Ahsan Khan  2 , Kaleem Ullah  3 , Haya Yasin  4 , Abdul Mannan  2 , Shujaat Ali Khan  2 , Ghulam Murtaza  5
Affiliations

Formulation and characterization of glipizide solid dosage form with enhanced solubility

Badriyah Shadid Alotaibi et al. PLoS One. .

Abstract

Glipizide, a poor water-soluble drug belongs to BCS class II. The proposed work aimed to enhance the solubility of glipizide by preparing solid dispersions, using polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG). Solvent evaporation method was used for the preparation of glipizide solid dispersions. Solid dispersions were prepared in four different drug-to-polymer ratios i.e. 1:1, 1:2, 1:3 and 1:4. Mainly effect of three polymers (PVP K30, PVP K90 and PEG 6000) was evaluated on the solubility and dissolution of glipizide. The in-vitro dissolution of all prepared formulations was performed under pH 6.8 at 37°C using USP type II apparatus. In-vitro dissolution results revealed that the formulations having high concentrations of the polymer showed enhanced solubility. Enhancements in the solubility and rate of dissolution of the drug were noted in solid dispersion formulations compared to the physical blends and pure drug. Solid dispersions containing polyvinyl pyrrolidone exhibited a more favorable pattern of drug release compared to the corresponding solid dispersions with PEG. An increase in the maximum solubility of the drug within the solid dispersion systems was observed in all instances. Two solid dispersion formulations were optimized and formulated into immediate-release tablets, which passed all the pharmacopoeial and non-pharmacopoeial tests. Fourier transformed Infrared (FTIR) spectroscopy X-ray diffraction (XRD) and Differential scanning calorimetry (DSC) were used to indicate drug: polymer interactions in solid state. Analysis of the solid dispersion samples through characterization tests indicated the compatibility between the drug and the polymer.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Dissolution profile of pure drug and PMs of each polymer.
Fig 2
Fig 2. Dissolution profile of pure glipizide and SD of PVP K30.
Fig 3
Fig 3. Dissolution profile of pure glipizide and SD of PEG 6000.
Fig 4
Fig 4. Dissolution profile of pure glipizide and SD of PVP K90.
Fig 5
Fig 5. Dissolution profile of tablets.
Fig 6
Fig 6. FTIR spectrum of glipizide, PVP K30, PVP K90 and optimized solid dispersions.
Fig 7
Fig 7. XRD diffractogram of glipizide, PVP K30, PVP K90 and optimized solid dispersions.
Fig 8
Fig 8. DSC of glipizide, PVP K30, PVP K90 and optimized solid dispersions.
See this image and copyright information in PMC

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