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. 2024 Feb 14;25(4):2274.
doi: 10.3390/ijms25042274.

The Association of ADAMTS7 Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study

Joanna Iwanicka  1 , Anna Balcerzyk-Matić  1 , Tomasz Iwanicki  1 , Katarzyna Mizia-Stec  2 , Paweł Bańka  2 , Artur Filipecki  2 , Katarzyna Gawron  3 , Alicja Jarosz  1 , Tomasz Nowak  1 , Jolanta Krauze  4 , Paweł Niemiec  1
Affiliations

The Association of ADAMTS7 Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study

Joanna Iwanicka et al. Int J Mol Sci. .

Abstract

The aim of this study was to investigate whether the polymorphisms of the ADAMTS7 gene affect the risk of occurrence and mortality due to CAD. The study group included 231 patients diagnosed with CAD and 240 control blood donors. The genotyping of specified polymorphisms, i.e., rs1994016, rs3825807, and rs7173743, was performed using the TaqMan-PCR. We found that the C allele carriers of the rs1994016 and A allele carriers of the rs3825807 polymorphisms increased the risk of CAD, respectively: OR = 1.72, p = 0.036; OR = 1.64, p = 0.04. Moreover, we studied the biological interactions of specified variants, i.e., rs3825807, rs1994016, and rs7173743, and previously approved risk factors of CAD. We demonstrated here that selected polymorphisms of ADAMTS7 increased the risk of CAD altogether with abnormalities of total cholesterol and LDL concentrations in serum. Although survival analyses did not reveal statistical significance, we observed a trend for the AA genotype of the rs3825807 ADAMTS7, which may predispose to death due to CAD in a 5-year follow-up. In conclusion, the ADAMTS7 polymorphisms investigated in this study may increase the risk of occurrence and/or death due to CAD in the Polish population.

Keywords: ADAMTS7; coronary artery disease; lipids; mortality; polymorphism.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Haplotype analysis of ADAMTS7 gene polymorphisms in the study group. (A) D’ values; (B) R2 values; (C) frequency of diplotypes of rs1994016 and rs3825807 SNPs.
Figure 2
Figure 2
Identified interactions of the ADAMTS7 gene polymorphisms and elevated levels of total cholesterol and LDL cholesterol (A), corresponding odds ratio values (B), and measures of interaction (C). Legend: AP, attributable proportion due to interaction; CI, confidence interval; LDL, low-density lipoprotein; OR, odds ratio; RERI, relative excess risk due to interaction; SI, synergy index; SIM, multiplicative synergy index; TC, total cholesterol.
Figure 3
Figure 3
Kaplan–Meier survival curves for CAD patients by rs1994016: (A) additive model: for 5-year survival, χ2 = 2.094, p = 0.351; for 10-year survival, χ2 = 0.405, p = 0.817. (B) Recessive model: for 5-year survival, the log-rank statistic was −1.374, p = 0.170; for 10-year survival, the log-rank statistic was −0.523, p = 0.601.
Figure 4
Figure 4
Kaplan–Meier survival curves for CAD patients by rs3825807: (A) additive model: for 5-year survival, χ2 = 2.928, p = 0.231; for 10-year survival, χ2 = 0.609, p = 0.737. (B) Recessive model: for 5-year survival, the log-rank statistic was −1.424, p = 0.155; for 10-year survival, the log-rank statistic was −0.650, p = 0.516.
Figure 5
Figure 5
Kaplan–Meier survival curves for CAD patients by rs7173743: (A) additive model: for 5-year survival, χ2 = 0.604, p = 0.739; for 10-year survival, χ2 = 0.506, p = 0.776. (B) Recessive model: for 5-year survival, the log-rank statistic was −0.206, p = 0.837; for 10-year survival, the log-rank statistic was 0.359, p = 0.719.
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