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Randomized Controlled Trial
. 2024 Feb 10;21(2):207.
doi: 10.3390/ijerph21020207.

The Association between Message Framing and Intention to Vaccinate Predictive of Hepatitis A Vaccine Uptake

Nora Satybaldiyeva  1 , Lourdes S Martinez  2 , Brittany Cooper  1 , Eyal Oren  1
Affiliations
Randomized Controlled Trial

The Association between Message Framing and Intention to Vaccinate Predictive of Hepatitis A Vaccine Uptake

Nora Satybaldiyeva et al. Int J Environ Res Public Health. .

Abstract

As ongoing, sporadic outbreaks of hepatitis A virus (HAV) infections present public health challenges, it is critical to understand public perceptions about HAV, especially regarding vaccination. This study examines whether message framing changes the intention to vaccinate against HAV and self-reported vaccine behavior. Using a randomized controlled trial (N = 472) in February 2019 via Amazon Mechanical Turk, participants were randomized to one of four HAV vaccination message groups or a no-message control group. The message groups varied in their emphasis on the nature of outcomes (gain versus loss) and for whom (individual versus collective). The message frames were compared by intention to vaccinate, differences in message characteristics, and behavioral determinants. There was no difference in intention to vaccinate between gain- versus loss-framed messages (MD = 0.1, 95% CI = -0.1, 0.3) and individual- versus collective-framed messages (MD = 0.1, 95% CI = -0.1, 0.3). The intention to vaccinate against HAV in the no-message control group was very similar to that in the message groups. However, gain-framed messages were rated more positively in valence than loss-framed messages (MD = -0.5, 95% CI = -0.7, -0.3), which may be helpful for cultivating a positive public perception of HAV vaccination. The study also highlights the importance of comparing message frames to a no-message control in designing health communication messaging promoting HAV vaccination.

Keywords: hepatitis A virus; intention; random allocation; vaccination intention; vaccine.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram depicting the derivation of the analytic study sample.
See this image and copyright information in PMC

References

    1. Franco E., Meleleo C., Serino L., Sorbara D., Zaratti L. Hepatitis A: Epidemiology and prevention in developing countries. World J. Hepatol. 2012;4:68. doi: 10.4254/wjh.v4.i3.68. - DOI - PMC - PubMed
    1. Foster M.A., Hofmeister M.G., Kupronis B.A., Lin Y., Xia G.-L., Yin S., Teshale E. Increase in hepatitis A virus infections—United States, 2013–2018. Morb. Mortal. Wkly. Rep. 2019;68:413. doi: 10.15585/mmwr.mm6818a2. - DOI - PMC - PubMed
    1. Foster M., Ramachandran S., Myatt K., Donovan D., Bohm S., Fiedler J., Barbeau B., Collins J., Thoroughman D., McDonald E., et al. Hepatitis A virus outbreaks associated with drug use and homelessness—California, Kentucky, Michigan, and Utah, 2017. Morb. Mortal. Wkly. Rep. 2018;67:1208. doi: 10.15585/mmwr.mm6743a3. - DOI - PMC - PubMed
    1. CDC . Multistate Outbreak of Hepatitis A Virus Infections Linked to Fresh Organic Strawberries. CDC; Atlanta, GA, USA: 2022.
    1. Acheson D., Fiore A.E. Hepatitis A transmitted by food. Clin. Infect. Dis. 2004;38:705–715. - PubMed

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