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Review
. 2024 Feb 8;12(2):400.
doi: 10.3390/biomedicines12020400.

Role of Helicobacter pylori Infection in Pathogenesis, Evolution, and Complication of Atherosclerotic Plaque

Tiziana Ciarambino  1 , Pietro Crispino  2 , Giovanni Minervini  3 , Mauro Giordano  4
Affiliations
Review

Role of Helicobacter pylori Infection in Pathogenesis, Evolution, and Complication of Atherosclerotic Plaque

Tiziana Ciarambino et al. Biomedicines. .

Abstract

The therapeutic management of atherosclerosis focuses almost exclusively on the reduction of plasma cholesterol levels. An important role in the genesis and evolution of atherosclerosis is played by chronic inflammation in promoting thrombosis phenomena after atheroma rupture. This review aims to take stock of the knowledge so far accumulated on the role of endemic HP infection in atherosclerosis. The studies produced so far have demonstrated a causal relationship between Helicobacter pylori (HP) and CVD. In a previous study, we demonstrated in HP-positive patients that thrombin and plasma fragment 1 + 2 production was proportionally related to tumor necrosis factor-alpha levels and that eradication of the infection resulted in a reduction of inflammation. At the end of our review, we can state that HP slightly affects the risk of CVD, particularly if the infection is associated with cytotoxic damage, and HP screening could have a clinically significant role in patients with a high risk of CVD. Considering the high prevalence of HP infection, an infection screening could be of great clinical utility in patients at high risk of CVD.

Keywords: Helicobacter pylori; atherosclerotic plaque; pathogenesis.

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Conflict of interest statement

The authors declare that haven’t conflict of interest.

Figures

Figure 1
Figure 1
Major determinates in the atherosclerosis process.
Figure 2
Figure 2
Evidence in favor of a possible role in H. pylori and atherosclerosis.
Figure 3
Figure 3
Evidence in favor of a possible role in H. pylori and Atherosclerosis.
See this image and copyright information in PMC

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