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. 2024 Feb 6;16(4):681.
doi: 10.3390/cancers16040681.

Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Marija Bušić  1 , Zoran Rumboldt  2 , Dora Čerina  3 , Željko Bušić  1 , Krešimir Dolić  1   4   5
Affiliations

Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas

Marija Bušić et al. Cancers (Basel). .

Abstract

This study aimed to evaluate potential posttreatment changes in ADC values within the tissue surrounding the enhancing lesion, particularly in areas not exhibiting MRI characteristics of involvement. Additionally, the objective was to investigate the correlations among ADC values, treatment response, and survival outcomes in individuals diagnosed with gliomas. This retrospective study included a total of 49 patients that underwent either stereotactic biopsy or maximal surgical resection. Histologically confirmed as Grade III or IV gliomas, all cases adhered to the 2016 and 2021 WHO classifications, with subsequent radio-chemotherapy administered post-surgery. Patients were divided into two groups: short and long survival groups. Baseline and follow-up MRI scans were obtained on a 1.5 T MRI scanner. Two ROI circles were positioned near the enhancing area, one ROI in the NAWM ipsilateral to the neoplasm and another symmetrically in the contralateral hemisphere on ADC maps. At follow-up there was a significant difference in both ipsilateral and contralateral NAWM between the two groups, -0.0857 (p = 0.004) and -0.0607 (p = 0.037), respectively. There was a weak negative correlation between survival and ADC values in ipsilateral and contralateral NAWM at the baseline with the correlation coefficient -0.328 (p = 0.02) and -0.302 (p = 0.04), respectively. The correlation was stronger at the follow-up. The findings indicate that ADC values in normal-appearing white matter (NAWM) may function as a prognostic biomarker in patients with diffuse gliomas.

Keywords: apparent diffusion coefficient; biomarkers; glioma; magnetic resonance imaging.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
ROI placement. (A): T1 axial spin-echo showing the enhancing lesion; (B): axial FLAIR showing white matter hyperintensity adjacent to the enhancing lesion; (C): axial ADC map showing ROI placement adjacent to the enhancing lesion; (D): axial FLAIR showing normal-appearing white matter; (E): axial ADC at the same level as “D” showing ROI placement.
Figure 2
Figure 2
Mean ADC values for both groups at baseline.
Figure 3
Figure 3
Mean ADC values for both groups at follow-up.
See this image and copyright information in PMC

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