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. 2024 Feb 19;13(4):1159.
doi: 10.3390/jcm13041159.

Linear IgA Bullous Dermatosis in Korea Using the Nationwide Health Insurance Database

Yu Rim Kim  1 , Ji Hyeon Kim  1 , Sang Won Kim  2 , Jae Min Lee  3 , Jacob S Bae  4
Affiliations

Linear IgA Bullous Dermatosis in Korea Using the Nationwide Health Insurance Database

Yu Rim Kim et al. J Clin Med. .

Abstract

(1) Background: Linear immunoglobulin A bullous dermatosis (LABD) is a rare autoimmune, subepidermal blistering disease, characterized by linear IgA deposits along the epidermal basement membrane. LABD is idiopathic and is associated with medication and systemic autoimmune diseases. (2) Methods: We investigated the demographic characteristics, disease course, causative agents, and associated diseases in Korean patients with LABD. The Korean Health Insurance Review and Assessment Service database was used to obtain data. We identified 670 LABD cases between 2010 and 2022. (3) Results: The annual incidence of LABD was 1.3 per 100,000 persons, with a higher prevalence in individuals ≥60 years old. The patients were treated with dapsone for 30.7 ± 56.7 days, had 1.3 ± 0.7 hospital visits, and were hospitalized for 19.8 ± 19.7 days. Risk factors, including malignancy, commonly preceded LABD. Antibiotic use, specifically vancomycin and third-generation cephalosporins, was a risk factor. The mean age of LABD diagnosis was 55.9 ± 21.7 years. (4) Conclusion: This is the first published study to assess a nationwide cohort for LABD. The incidence of LABD was higher than that in other studies. Most case reports have linked LABD with the administration of specific antibiotics; however, this study shows there were more associations with other conditions.

Keywords: Korea; antibiotics; epidemiology; linear immunoglobulin A bullous dermatosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart illustrating patient selection.
Figure 2
Figure 2
(A) Monthly incidence of linear IgA bullous dermatosis during study period. (B) Monthly trend of linear IgA bullous dermatosis. (C) Seasonal trend of linear IgA bullous dermatosis.
Figure 2
Figure 2
(A) Monthly incidence of linear IgA bullous dermatosis during study period. (B) Monthly trend of linear IgA bullous dermatosis. (C) Seasonal trend of linear IgA bullous dermatosis.
Figure 3
Figure 3
Annual trend analysis of linear IgA bullous dermatosis by age group.
Figure 4
Figure 4
Systemic disease associated with LABD.
Figure 5
Figure 5
Frequency of antibiotic use concurrent with LABD biopsy.
See this image and copyright information in PMC

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