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Review
. 2024 Feb 15;29(4):865.
doi: 10.3390/molecules29040865.

The Promising Role of Polyphenols in Skin Disorders

Mohd Farhan  1   2
Affiliations
Review

The Promising Role of Polyphenols in Skin Disorders

Mohd Farhan. Molecules. .

Abstract

The biochemical characteristics of polyphenols contribute to their numerous advantageous impacts on human health. The existing research suggests that plant phenolics, whether consumed orally or applied directly to the skin, can be beneficial in alleviating symptoms and avoiding the development of many skin disorders. Phenolic compounds, which are both harmless and naturally present, exhibit significant potential in terms of counteracting the effects of skin damage, aging, diseases, wounds, and burns. Moreover, polyphenols play a preventive role and possess the ability to delay the progression of several skin disorders, ranging from small and discomforting to severe and potentially life-threatening ones. This article provides a concise overview of recent research on the potential therapeutic application of polyphenols for skin conditions. It specifically highlights studies that have investigated clinical trials and the use of polyphenol-based nanoformulations for the treatment of different skin ailments.

Keywords: clinical trials; human health; nanoformulations; polyphenols; skin disorder.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Polyphenols are classified as phenolic acids, flavonoids, stilbenes, and lignans based on their structure and the numbering of carbons.
Figure 2
Figure 2
The versatile use of multifaceted polyphenols in treating various skin conditions.
Figure 3
Figure 3
Summary of the effects of polyphenols on skin health and their underlying mechanisms. The anticancer benefits of polyphenols can be attributed to their antioxidant characteristics, along with other associated positive effects.
Figure 4
Figure 4
The potential role of polyphenols in the treatment of significant skin disorders. The potential of polyphenols as an additional therapeutic, along with their ability to mitigate deleterious effects, could also improve the negative consequences caused by sunshine exposure.
Figure 5
Figure 5
Diverse nanostructured molecules are employed in the creation of nanoformulations for the delivery of polyphenols in skin treatment.
See this image and copyright information in PMC

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