SENOSI Confocal Microscopy: A New and Innovating Way to Detect Positive Margins in Non-Palpable Breast Cancer?
- PMID: 38398713
- PMCID: PMC10890637
- DOI: 10.3390/life14020204
SENOSI Confocal Microscopy: A New and Innovating Way to Detect Positive Margins in Non-Palpable Breast Cancer?
Abstract
In Switzerland, breast cancer is the leading cancer among women, with breast-conserving surgery (BCS) being the preferred treatment for small tumors. The margin status post-surgery is a critical predictor of local recurrence. Achieving negative margins remains a challenge, leading to re-excision in 20-30% of cases. Traditional methods like intraoperative examination palpation and radiography have limitations in assessing excised margins. This study introduces the Histolog® Scanner, a confocal microscopy tool, as a potential solution. It provides real-time images of tissue architecture, allowing for rapid and accurate assessment of excised margins. Our research compared the Histolog® Scanner with standard per-operative radiography in patients with non palpable breast cancer. Preliminary results indicate that the Histolog® Scanner offers a reliable and time-efficient method for margin assessment, suggesting its potential for clinical integration.
Keywords: breast cancer; confocal microscopy; margins; surgery.
Conflict of interest statement
The authors declare no conflict of interest.
Figures








References
-
- World Health Organization: Regional Office for Europe . World Cancer Report: Cancer Research for Cancer Development. IARC; Lyon, France: 2020.
-
- Ligue Suisse Contre le Cancer Le Cancer en Suisse: Les Chiffres Période Déterminante: 2015–2019 (Moyenne Annuelle) 2022. [(accessed on 27 November 2023)]. Available online: https://www.bfs.admin.ch/bfs/fr/home/actualites/quoi-de-neuf.assetdetail....
-
- Yoon G.Y., Cha J.H., Kim H.H., Shin H.J., Chae E.Y., Choi W.J. Recurrent and Second Breast Cancer Detected on Follow-Up Mammography and Breast Ultrasound after Breast-Conserving Surgery: Imaging Findings and Clinicopathologic Factors. J. Korean Soc. Radiol. 2016;74:15. doi: 10.3348/jksr.2016.74.1.15. - DOI
-
- Atkins J., Mushawah F.A., Appleton C.M., Cyr A.E., Gillanders W.E., Aft R.L., Eberlein T.J., Gao F., Margenthaler J.A. Positive margin rates following breast-conserving surgery for stage I–III breast cancer: Palpable versus nonpalpable tumors. J. Surg. Res. 2012;177:109–115. doi: 10.1016/j.jss.2012.03.045. - DOI - PMC - PubMed
LinkOut - more resources
Full Text Sources