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Review
. 2024 Feb 24;51(1):359.
doi: 10.1007/s11033-023-08937-w.

Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions

Bin Wang #  1 , Mingxia Gao #  2   3 , Ying Yao  1 , Hongwei Li  1 , Xuehong Zhang  4   5
Affiliations
Review

Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions

Bin Wang et al. Mol Biol Rep. .

Abstract

The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase crucial for cellular differentiation, proliferation, and autophagy. It shows a complex role in the endometrium, influencing both normal and pathogenic conditions. mTOR promotes the growth and maturation of endometrial cells, enhancing endometrial receptivity and decidualization. However, it also contributes to the development of endometriosis (EMs) and endometrial cancer (EC), thus emerging as a therapeutic target for these conditions. In this review, we summarize recent research progress on the mTOR signalling pathway in the endometrium. This provides insights into female endometrial structure and function and guides the prevention and treatment of related diseases.

Keywords: Decidualization; Endometrial cancer; Endometrial receptivity; Endometriosis; Endometrium; mTOR.

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References

    1. Heitman J, Movva NR, Hall MN (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253(5022):905–909 - PubMed
    1. Condon KJ, Sabatini DM (2019) Nutrient regulation of mTORC1 at a glance. J Cell Sci 132(21):jcs222570 - PubMed - PMC
    1. Correia B, Sousa MI, Ramalho-Santos J (2020) The mTOR pathway in reproduction: from gonadal function to developmental coordination. Reproduction 159(4):R173–R188 - PubMed
    1. Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D (2021) Autophagy in the physiological endometrium and cancer. Autophagy 17(5):1077–1095 - PubMed
    1. Hussain T, Tan B, Murtaza G, Metwally E, Yang H, Kalhoro MS et al (2020) Role of dietary amino acids and nutrient sensing system in pregnancy associated disorders. Front Pharmacol 11:586979 - PubMed - PMC

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