Review

. 2024 Apr;26(4):346-358.

doi: 10.1007/s11912-024-01500-1. Epub 2024 Feb 24.

An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients

Alessandra Fabi¹, Alessandro Rossi^{2

3}, Edoardo Mocini⁴, Ludovica Cardinali^{4

5}, Valerio Bonavolontà⁶, Cristina Cenci⁷, Stefano Magno⁸, Vittoria Barberi⁹, Antimo Moretti¹⁰, Zein Mersini Besharat⁴, Giovanni Iolascon¹⁰, Carlo Baldari¹¹, Elisabetta Ferretti⁴, Andrea Botticelli¹², Ida Paris¹³, Giovanni Scambia¹³, Silvia Migliaccio^{3

4}

Affiliations

¹ Precision Medicine Unit in Senology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. alessandra.fabi@policlinicogemelli.it.
² Precision Medicine Unit in Senology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.
³ Department of Movement, Human and Health Sciences, University Foro Italico of Rome, Rome, Italy.
⁴ Department of Experimental Medicine, University Sapienza of Rome, Rome, Italy.
⁵ Bone Metabolic Diseases Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
⁶ Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.
⁷ DNM-Digital Narrative Medicine, Rome, Italy.
⁸ Center for Integrative Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁹ Medical Oncology 1, Regina Elena National Cancer Institute IRCCS, Rome, Italy.
¹⁰ Multidisciplinary Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Caserta, Italy.
¹¹ Department of Theoretical and Applied Sciences, eCampus University, Rome, Italy.
¹² Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
¹³ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

PMID: 38400984
PMCID: PMC11021235
DOI: 10.1007/s11912-024-01500-1

Review

An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients

Alessandra Fabi et al. Curr Oncol Rep. 2024 Apr.

. 2024 Apr;26(4):346-358.

doi: 10.1007/s11912-024-01500-1. Epub 2024 Feb 24.

Authors

Affiliations

¹ Precision Medicine Unit in Senology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy. alessandra.fabi@policlinicogemelli.it.
² Precision Medicine Unit in Senology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.
³ Department of Movement, Human and Health Sciences, University Foro Italico of Rome, Rome, Italy.
⁴ Department of Experimental Medicine, University Sapienza of Rome, Rome, Italy.
⁵ Bone Metabolic Diseases Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
⁶ Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila, Italy.
⁷ DNM-Digital Narrative Medicine, Rome, Italy.
⁸ Center for Integrative Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁹ Medical Oncology 1, Regina Elena National Cancer Institute IRCCS, Rome, Italy.
¹⁰ Multidisciplinary Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Caserta, Italy.
¹¹ Department of Theoretical and Applied Sciences, eCampus University, Rome, Italy.
¹² Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
¹³ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

PMID: 38400984
PMCID: PMC11021235
DOI: 10.1007/s11912-024-01500-1

Abstract

Background: Breast cancer (BC) treatment has recently been revolutionized by the introduction of newer targeted agents, that helped tailoring therapies around the single patient. Along with increased survival rates, a careful evaluation of diet, lifestyle habits, physical activity, emotional and psychological experiences linked to the treatment journey, is now mandatory. However, a true proposal for an omnicomprehensive and "integrative" approach is still lacking in literature.

Methods: A scientific board of internationally recognized specialists throughout different disciplines designed a shared proposal of holistic approach for BC patients.

Results: A narrative review, containing information on BC treatment, endocrinological and diet aspects, physical activity, rehabilitation, integrative medicine, and digital narrative medicine, was developed.

Conclusions: In the context of a patient-centered care, BC treatment cannot be separated from a patient's long-term follow-up and care, and an organized interdisciplinary collaboration is the future in this disease's cure, to make sure that our patients will live longer and better.

Trial registration: NCT05893368: New Model for Integrating Person-based Care (PbC) in the Treatment of Advanced HER2-negative Breast Cancer (PERGIQUAL). Registration date: 29th May 2023.

Keywords: Breast cancer; Cancer prevention; Integrative oncology; Multidisciplinary approach; Oncology and metabolism; Personalized medicine; Tailored oncology.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
Integrative oncological approach for early and advanced breast cancer

See this image and copyright information in PMC

References

1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. - DOI - PubMed
1. Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015;347(6217):78–81. doi: 10.1126/science.1260825. - DOI - PMC - PubMed
1. Jiralerspong S, Goodwin PJ. obesity and breast cancer prognosis: evidence, challenges, and opportunities. J Clin Oncol. 2016;34(35):4203–4216. doi: 10.1200/JCO.2016.68.4480. - DOI - PubMed
1. Pérez-Solis MA, Maya-Nuñez G, Casas-González P, et al. Effects of the lifestyle habits in breast cancer transcriptional regulation. Cancer Cell Int. 2016;13(16):7. doi: 10.1186/s12935-016-0284-7. - DOI - PMC - PubMed
1. Fiocchetti M, Bastari G, Cipolletti M, et al. The peculiar estrogenicity of diethyl phthalate: modulation of estrogen receptor Α activities in the proliferation of breast cancer cells. Toxics. 2021;9:237. doi: 10.3390/toxics9100237. - DOI - PMC - PubMed

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An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients

Affiliations

An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients

Authors

Affiliations

Abstract

Conflict of interest statement

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Associated data

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