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Review
. 2024 Apr:78:102439.
doi: 10.1016/j.mib.2024.102439. Epub 2024 Feb 23.

Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens

Feng Yang  1 , Judith Berman  2
Affiliations
Review

Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens

Feng Yang et al. Curr Opin Microbiol. 2024 Apr.

Abstract

Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand the routes by which antifungal heteroresistance and tolerance emerge.

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Conflict of interest statement

Declaration of Competing Interest I declare that I have no conflicts of interest and I am not involved in any commercial work that relates to this review.

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