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Review
. 2024 Apr;33(2):343-367.
doi: 10.1016/j.soc.2023.12.016. Epub 2024 Jan 24.

Precision Oncology in Hepatopancreatobiliary Cancer Surgery

Timothy E Newhook  1 , Susan Tsai  2 , Funda Meric-Bernstam  3
Affiliations
Review

Precision Oncology in Hepatopancreatobiliary Cancer Surgery

Timothy E Newhook et al. Surg Oncol Clin N Am. 2024 Apr.

Abstract

Advances in technology have allowed for the characterization of tumors at the genomic, transcriptomic, and proteomic levels. There are well-established targets for biliary tract cancers, with exciting new targets emerging in pancreatic ductal adenocarcinoma and potential targets in hepatocellular carcinoma. Taken together, these data suggest an important role for molecular profiling for personalizing cancer therapy in advanced disease and need for design of novel neoadjuvant studies to leverage these novel therapeutics perioperatively in the surgical patient.

Keywords: Cholangiocarcinoma; Genomics; Liver cancer; Pancreatic cancer; Targeted therapy.

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Conflict of interest statement

Disclosure T.E. Newhook and S. Tsai report no disclosures. F. Meric-Bernstam reports Consulting fees from AbbVie, Aduro BioTech Inc., Alkermes, AstraZeneca, Daiichi Sankyo Co. Ltd., Calibr (a division of Scripps Research), DebioPharm, Ecor1 Capital, eFFECTOR Therapeutics, F. Hoffman-La Roche Ltd., GT Apeiron, Genentech Inc., Harbinger Health, IBM Watson, Incyte, Infinity Pharmaceuticals, Jackson Laboratory, Kolon Life Science, LegoChem Bio, Lengo Therapeutics, Menarini Group, OrigiMed, PACT Pharma, Parexel International, Pfizer Inc., Protai Bio Ltd, Samsung Bioepis, Seattle Genetics Inc., Tallac Therapeutics, Tyra Biosciences, Xencor, Zymeworks; serves on Advisory Committees for Black Diamond, Biovica, Eisai, FogPharma, Immunomedics, Inflection Biosciences, Karyopharm Therapeutics, Loxo Oncology, Mersana Therapeutics, OnCusp Therapeutics, Puma Biotechnology Inc., Seattle Genetics, Sanofi, Silverback Therapeutics, Spectrum Pharmaceuticals, Theratechnologies, Zentalis; receives Sponsored Research (to her institution) from Aileron Therapeutics, United States. AstraZeneca, United Kingdom, Bayer Healthcare Pharmaceutical, Calithera Biosciences, United States, Curis Inc., CytomX Therapeutics Inc., Daiichi-Sankyo, Japan, Debiopharm International, eFFECTOR Therapeutics, United States, Genentech, United States, Guardant Health Inc., Klus Pharma, Takeda Pharmaceutical, Novartis, Switzerland, Puma Biotechnology, United States, Taiho Pharmaceutical Co., Japan; has received Honoraria from Dava Oncology, and nonfinancial support and reasonable reimbursement for travel from European Organisation for Research and Treatment of Cancer (EORTC), Belgium, European Society for Medical Oncology (ESMO), Switzerland, Cholangiocarcinoma Foundation, United States, Dava Oncology.