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. 2024 May:194:110180.
doi: 10.1016/j.radonc.2024.110180. Epub 2024 Feb 24.

Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers

Masashi Koto  1 , Hiroaki Ikawa  2 , Taku Inaniwa  3 , Reiko Imai  2 , Makoto Shinoto  2 , Hirotoshi Takiyama  2 , Tetsuro Isozaki  2 , Hideyuki Mizuno  3 , Ryosuke Kohno  4 , Ikumi Takahashi  5 , Naoki Yoshida  5 , Shigeru Yamada  2
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Free article

Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers

Masashi Koto et al. Radiother Oncol. 2024 May.
Free article

Abstract

This feasibility study confirmed the initial safety and efficacy of a novel carbon-ion radiotherapy (CIRT) using linear energy transfer (LET) painting for head and neck cancer. This study is the first step toward establishing CIRT with LET painting in clinical practice and making it a standard practice in the future.

Keywords: Carbon-ion radiotherapy; Dose-averaged LET; Head and neck cancer; LET optimization; LET painting.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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