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. 2024 Feb;18(2):e13255.
doi: 10.1111/irv.13255.

Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network

Angela M C Rose  1 , Francisco Pozo  2   3 , Iván Martínez-Baz  3   4 , Clara Mazagatos  3   5 , Nathalie Bossuyt  6 , John Paul Cauchi  7 , Goranka Petrović  8 , Isabela I Loghin  9 , Roberta Vaikutyte  10 , Silke Buda  11 , Ausenda Machado  12 , Róisín Duffy  13 , Beatrix Oroszi  14 , Jennifer Howard  1 , Aitziber Echeverria  3   4 , Cristina Andreu  15 , Cyril Barbezange  6 , Aušra Džiugytė  7 , Diana Nonković  16 , Corneliu-Petru Popescu  17 , Fausta Majauskaite  18 , Kristin Tolksdorf  11 , Verónica Gomez  12 , Lisa Domegan  13 , Judit Krisztina Horváth  14 , Jesús Castilla  3   4 , Miriam García  19 , Thomas Demuyser  20 , Maria-Louise Borg  7 , Irena Tabain  8 , Mihaela Lazar  21 , Ieva Kubiliute  18 , Ralf Dürrwald  11 , Raquel Guiomar  12 , Joan O'Donnell  13 , Katalin Kristóf  14 , Nathalie Nicolay  22 , Sabrina Bacci  22 , Esther Kissling  1 ; VEBIS SARI VE network team; Belgium SARI Surveillance Network (BelsariNet)
Collaborators, Affiliations

Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network

Angela M C Rose et al. Influenza Other Respir Viruses. 2024 Feb.

Abstract

We conducted a multicentre hospital-based test-negative case-control study to measure vaccine effectiveness (VE) against PCR-confirmed influenza in adult patients with severe acute respiratory infection (SARI) during the 2022/2023 influenza season in Europe. Among 5547 SARI patients ≥18 years, 2963 (53%) were vaccinated against influenza. Overall VE against influenza A(H1N1)pdm09 was 11% (95% CI: -23-36); 20% (95% CI: -4-39) against A(H3N2) and 56% (95% CI: 22-75) against B. During the 2022/2023 season, while VE against hospitalisation with influenza B was >55%, it was ≤20% for influenza A subtypes. While influenza vaccination should be a priority for future seasons, improved vaccines against influenza are needed.

Keywords: SARI patients; hospital; influenza; test-negative design; vaccine effectiveness.

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Conflict of interest statement

No conflict of interest declared.

Figures

FIGURE 1
FIGURE 1
Countries and study sites participating in the Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital network by provision of data for this analysis, Europe, 2022–2023 influenza season. Participating sites: Belgium (BE), Croatia (HR), Czechia (CZ), France (FR), Germany (DE), Hungary (HU), Ireland (IE), Lithuania (LT), Malta (MT), Portugal (PT), Romania (RO), Spain (11 regions: ES; Navarra region: NA). Included in this analysis: BE, ES, DE, HR, LT, MT, NA, PT, RO.
FIGURE 2
FIGURE 2
Number of severe acute respiratory infection (SARI) patients by case status and week of vaccination or swab, Vaccine Effectiveness, Burden and Impact Studies (VEBIS) in the hospital setting, influenza 2022/2023 season, Europe (N = 5547).
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