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Review
. 2024 Oct;103(10):3867-3880.
doi: 10.1007/s00277-024-05678-z. Epub 2024 Feb 26.

Advances in the ocular complications after hematopoietic stem cell transplantation

Xiaoli Lv  1 , Huibo Li  1 , Sheng Su #  2 , Shengjin Fan #  3   4
Affiliations
Review

Advances in the ocular complications after hematopoietic stem cell transplantation

Xiaoli Lv et al. Ann Hematol. 2024 Oct.

Abstract

Hematopoietic stem cell transplantation (HSCT) has benefited an increasing number of patients with hematological disease in the clinic. It is a curative therapy for malignant and nonmalignant hematological diseases. With the advancement and further clinical application of HSCT in recent years, the life expectancy of patients has increased, but complications have become more common. The occurrence of ocular complications is receiving increasing attention because they can seriously affect the quality of life of patients. Ocular complications require increased attention from clinicians because of their negative impact on patients and increasing incidence. Most of recent reports on posttransplant ocular complications involve ocular manifestations of graft-versus-host disease (GVHD), and a few ocular complications that do not originate from GVHD have also been reported. This review summarizes the diagnosis, scoring criteria, pathophysiology, and clinical manifestations of and common therapies for ocular graft-versus-host disease(oGVHD) after HSCT, and includes a description of some rare cases and novel therapies.

Keywords: Graft-versus-host disease(GVHD); Hematopoietic stem cell transplantation (HSCT); Ocular complications; Ocular graft-versus-host disease (oGVHD).

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