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. 2024 Apr 24;63(18):e202401838.
doi: 10.1002/anie.202401838. Epub 2024 Mar 12.

Modular Synthesis of Improbable Rotaxanes with All-Benzene Scaffolds

An Bu  1 , Jia-Nan Gao  1 , Yiming Chen  1 , Hongyan Xiao  2 , Hongwei Li  3 , Chen-Ho Tung  1 , Li-Zhu Wu  1 , Huan Cong  1
Affiliations

Modular Synthesis of Improbable Rotaxanes with All-Benzene Scaffolds

An Bu et al. Angew Chem Int Ed Engl. .

Abstract

"Improbable" rotaxanes consisting of interlocked conjugated components represent non-trivial synthetic targets, not to mention those with all-benzene scaffolds. Herein, a modular synthetic strategy has been established using an isolable azo-linked pre-rotaxane as the core module, in which the azo group functions as a tracelessly removable template to direct mechanical bond formations. Through versatile connections of the pre-rotaxane and other customizable modules, [2]- and [3]rotaxanes derived from all-benzene scaffolds have been accomplished, demonstrating the utility and potential of the synthetic design for all-benzene interlocked supramolecules.

Keywords: all-benzene scaffolds; azobenzene; cycloparaphenylenes; modular synthesis; rotaxanes.

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References

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