Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb 9:11:1321325.
doi: 10.3389/fsurg.2024.1321325. eCollection 2024.

Safety and efficacy revisited: a systematic review and meta-analysis of glue versus tack mesh fixation in laparoscopic inguinal herniorrhaphy

Sandesh Raja  1 , Adarsh Raja  2 , Ziyan Ansari  1 , Sara Eman  3 , Simran Bajaj  4 , Muhammad Ahmed  2 , Uday Kumar  2 , Yawar Hussain Shah  2 , Sachin Jawahar  5 , Faisal Aftab  2 , Deepak Rajani  2 , Satesh Kumar  2 , Mahima Khatri  1
Affiliations
Review

Safety and efficacy revisited: a systematic review and meta-analysis of glue versus tack mesh fixation in laparoscopic inguinal herniorrhaphy

Sandesh Raja et al. Front Surg. .

Abstract

Background: This analysis addresses the uncertainty surrounding the efficacy of glue mesh fixation (GMF) compared with tack mesh fixation (TMF) in laparoscopic herniorrhaphy. Our meta-analysis incorporates recently conducted randomized controlled trials (RCTs) to enhance the reference for assessing the efficacy and safety of GMF.

Methods: PubMed Central, Google Scholar, Science Direct, and Cochrane Library were extensively reviewed for articles in the English language performed from inception to May 2023 using the keywords "Glue mesh repair," "Tack mesh repair," "Inguinal Hernia," "Herniorrhaphy," "Laparoscopic," "Mesh Fixation," and "Randomized controlled trials."

Results: In this meta-analysis, we incorporated a total of 20 randomized controlled trials, evaluating each article individually using quality ratings. Compared with TMF, GMF demonstrated a significant reduction in the incidence of chronic pain [RR: 0.40, (0.23, 0.68)] and pain scores on postoperative day 1 [MD: -1.07, (-1.90, -0.25)]. We also used funnel plots and Egger's regression to test for publication bias.

Conclusion: In summary, this meta-analysis establishes the significance of GMF in reducing chronic pain and postoperative day 1 pain compared with TMF. However, no statistically significant difference was noted between the GMF and TMF groups concerning hematoma, seroma, operation time, recurrence rate, and total complications. Nonetheless, given the small number of cases in this study, the findings must be validated in the future by multicenter, large-sample, high-quality RCTs.

Keywords: glue mesh fixation; hernia; inguinal hernia; laparoscopic herniorrhaphy; tack mesh fixation.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart.
Figure 2
Figure 2
Risk of bias graph.
Figure 3
Figure 3
Risk of bias summary.
Figure 4
Figure 4
Forest plot of rate of chronic pain.
Figure 5
Figure 5
Forest plot of rate of pain score on postoperative day 1.
Figure 6
Figure 6
Forest plot of rate of operation time.
Figure 7
Figure 7
Forest plot of rate of recurrence rate.
Figure 8
Figure 8
Forest plot of rate of hematoma.
Figure 9
Figure 9
Forest plot of rate of seroma.
Figure 10
Figure 10
Forest plot of rate of total complications.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Slater BJ, Pimpalwar A. Abdominal wall defects. Neoreviews. (2020) 21(6):e383–91. 10.1542/NEO.21-6-E383 - DOI - PubMed
    1. Inguinal Hernia - PubMed. https://pubmed.ncbi.nlm.nih.gov/30020704/ (Accessed December 16, 2023).
    1. Morrison Z, Kashyap S, Nirujogi VL. Adult inguinal hernia. StatPearls. Published online (2023).https://pubmed.ncbi.nlm.nih.gov/30725926/ (Accessed June 10, 2023). - PubMed
    1. Ihedioha U, Alani A, Modak P, Chong P, O’Dwyer PJ. Hernias are the most common cause of strangulation in patients presenting with small bowel obstruction. Hernia. (2006) 10(4):338–40. 10.1007/S10029-006-0101-7 - DOI - PubMed
    1. Huckell R. Strangulated hernia. Br Med J. (2023) 1(3828):917–8. 10.1136/bmj.1.3828.917-a - DOI

LinkOut - more resources