Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 18;15(2):863-874.
doi: 10.1364/BOE.514994. eCollection 2024 Feb 1.

Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation

M Daniyal Ghauri  1   2 , Stefan Šušnjar  3   4 , Claudia Nunzia Guadagno  5 , Somdatta Bhattacharya  1 , Björn Thomasson  3 , Johannes Swartling  3 , Rekha Gautam  1 , Stefan Andersson-Engels  1   5   6 , Sanathana Konugolu Venkata Sekar  1   5
Affiliations

Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation

M Daniyal Ghauri et al. Biomed Opt Express. .

Abstract

Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model comprises of a photosensitizer-embedded gelatin lesion within a liquid Intralipid prostate shape that is surrounded by a solid silicone outer shell. The hybrid phantom was well characterized for optical properties. The final assembled phantom was also evaluated for fluorescence tomographic reconstruction in conjunction with SpectraCure's IDOSE software. The developed model can lead to advancements in dosimetric evaluations. This would improve PDT outlook as a clinical treatment modality and boost phantom based standardization of biophotonic devices globally.

PubMed Disclaimer

Conflict of interest statement

SKVS and SAE are shareholders of BioPixS Ltd with an interest in tissue optical phantoms. SAE and JSw are minority shareholders of SpectraCure AB with an interest in Prostate cancer IPDT.

Figures

Fig. 1.
Fig. 1.
(a) Tissue 3D structural layout based on the ultrasound data (b) CAD files for the anatomical features identified (Left to Right: Urethra, Prostate, Tumor, Rectum,) (c) Outer mold for the silicone phantom showing the placement of prostate inside(d) Optical properties at 690 nm [21,22].
Fig. 2.
Fig. 2.
Synthesis process of gelatin phantoms.
Fig. 3.
Fig. 3.
Schematic of optical arrangement used for characterizing gelatin phantoms.
Fig. 4.
Fig. 4.
Fiber positions for the tumor geometry (a) Lateral View (b) Top View.
Fig. 5.
Fig. 5.
Background Corrected: (a) Fluorescence emission results (b) Proportionality plot between fluorescence intensity and PS concentration (c) Photobleaching effect in gelatin phantom.
Fig. 6.
Fig. 6.
(a) Final assembled hybrid phantom ready for measurement (b) Tomographic Reconstruction.
Fig. 7.
Fig. 7.
(a) Tumors for varying concentrations of verteporfin along with outer shell (b) Light delivery in gelatin tumor surrounded by liquid prostate within the lower half of the silicone outer shell.
See this image and copyright information in PMC

Update of

  • doi: 10.1364/opticaopen.24713385.

References

    1. Algorri J. F., Ochoa M., Roldán-Varona P., et al. , “Photodynamic therapy: A compendium of latest reviews,” Cancers 13(17), 4447 (2021).10.3390/cancers13174447 - DOI - PMC - PubMed
    1. Pogue B. W., Elliott J. T., Kanick S. C., et al. , “Revisiting photodynamic therapy dosimetry: Reductionist & surrogate approaches to facilitate clinical success,” Phys. Med. Biol. 61(7), R57–R89 (2016).10.1088/0031-9155/61/7/R57 - DOI - PubMed
    1. Kim M. M., Darafsheh A., “Light Sources and Dosimetry Techniques for Photodynamic Therapy,” Photochem. Photobiol. 96(2), 280–294 (2020).10.1111/php.13219 - DOI - PubMed
    1. Correia J. H., Rodrigues J. A., Pimenta S., et al. , “Photodynamic therapy review: Principles, photosensitizers, applications, and future directions,” Pharmaceutics 13(9), 1–16 (2021).10.3390/pharmaceutics13091332 - DOI - PMC - PubMed
    1. Pratavieira S., Uliana M. P., dos Santos Lopes N. S., et al. , “Photodynamic therapy with a new bacteriochlorin derivative: Characterization and in vitro studies,” Photodiagn. Photodyn. Ther. 34, 1–8 (2021).10.1016/j.pdpdt.2021.102251 - DOI - PubMed

LinkOut - more resources