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Comment
. 2024 Jan 16;15(2):789-792.
doi: 10.1364/BOE.504315. eCollection 2024 Feb 1.

Clarification on the understanding of contrast theory in relation to the article "ON and OFF receptive field processing in the presence of optical scattering": comment

Jay Neitz  1 , Maureen Neitz  1
Affiliations
Comment

Clarification on the understanding of contrast theory in relation to the article "ON and OFF receptive field processing in the presence of optical scattering": comment

Jay Neitz et al. Biomed Opt Express. .

Abstract

We are writing to address errors of misrepresentation in the article "ON and OFF receptive field processing in the presence of optical scattering" [Biomed. Opt. Express14, 2618 (2023)10.1364/BOE.489117]. In their investigation of predictions of "contrast theory" to explain the efficacy of diffusion optics technology (DOT), a myopia control lens design [Br. J. Ophthalmol.107, 1709 (2023)10.1136/bjo-2021-321005], Breher et al. incorrectly indicated that our contrast theory proposed that the association between cone opsin gene splicing defects and myopia was due to differential involvement in ON- and OFF-visual pathways. In addition, the Authors write that we have "hypothesized enhanced ON contrast sensitivity in myopes," but we predict the opposite.

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Conflict of interest statement

P: JN and MN are authors of patents on methods of myopia control held by the Medical College of Wisconsin and the University of Washington.

Comment on

References

    1. Breher K., Neumann A., Kurth D., et al. , “ON and OFF receptive field processing in the presence of optical scattering,” Biomed. Opt. Express 14(6), 2618–2628 (2023).10.1364/BOE.489117 - DOI - PMC - PubMed
    1. Rappon J., Chung C., Young G., et al. , “Control of myopia using diffusion optics spectacle lenses: 12-month results of a randomised controlled, efficacy and safety study (CYPRESS),” Br. J. Ophthalmol. 107, 1709 (2022).10.1136/bjo-2021-321005 - DOI - PMC - PubMed
    1. Greenwald S., Kuchenbecker J. A., Rowlan J. S., et al. , “Role of a dual splicing and amino acid code in myopia, cone dysfunction and cone dystrophy associated with L/M opsin interchange mutations,” Trans. Vis. Sci. Tech. 6(3), 2 (2017).10.1167/tvst.6.3.2 - DOI - PMC - PubMed
    1. Neitz M., Wagner-Schuman M., Rowlan J. S., et al. , “Insight from OPN1LW gene haplotypes into the cause and prevention of myopia,” Genes 13(6), 942 (2022).10.3390/genes13060942 - DOI - PMC - PubMed
    1. Neitz M., Neitz J., “Intermixing the OPN1LW and OPN1 MW genes disrupts the exonic splicing code causing an array of vision disorders,” Genes 12(8), 1180 (2021).10.3390/genes12081180 - DOI - PMC - PubMed

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