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Case Reports
. 2024 Feb 15:34:102020.
doi: 10.1016/j.ajoc.2024.102020. eCollection 2024 Jun.

Unsuccessful transscleral cyclophotocoagulation in oculocutaneous albinism

Aaron D Dotson  1 , John H Fingert  1   2 , Erin A Boese  1   2
Affiliations
Case Reports

Unsuccessful transscleral cyclophotocoagulation in oculocutaneous albinism

Aaron D Dotson et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To report a case of unsuccessful transscleral cyclophotocoagulation in a patient with OCA1A tyrosinase-negative oculocutaneous albinism.

Observations: A 35-year-old Asian female with molecularly diagnosed OCA1A (tyrosinase-negative) oculocutaneous albinism and unilateral severe mixed mechanism glaucoma underwent transscleral cyclophotocoagulation on two separate occasions to treat elevated intraocular pressure. The intraocular pressure remained markedly elevated approximately 1 month following two separate treatments of transscleral cyclophotocoagulation while using high energy settings. The poor efficacy of both cyclophotocoagulation treatments was most likely due to a lack of melanin in the setting of oculocutaneous albinism.

Conclusions and importance: Cyclophotocoagulation in patients with oculocutaneous albinism is less likely to yield a desired lowering of intraocular pressure due to the absence of melanin.

Keywords: Cyclophotocoagulation; Glaucoma; Oculocutaneous albinism.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
A. External photograph demonstrating amelanotic features, including skin, hair, and irides. Her left eye has a conformer in place following enucleation. B. Complete transillumination of the right iris with underlying posterior chamber intraocular lens fully visible. C. Wide-field fundus photograph of non-pigmented retina.
See this image and copyright information in PMC

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