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. 2024 Feb 7;10(4):e25995.
doi: 10.1016/j.heliyon.2024.e25995. eCollection 2024 Feb 29.

Trends in gut-heart axis and heart failure research (1993-2023): A bibliometric and visual analysis

Jiahui Ouyang  1   2 , Lingli Zhao  1   2 , Yewen Song  1 , Hua Qu  1   2 , Tianyi Du  1   2   3 , Liu Shi  1   2   3 , Zhijie Cui  1   2 , Zhonghui Jiang  1   2 , Zhuye Gao  1   2
Affiliations

Trends in gut-heart axis and heart failure research (1993-2023): A bibliometric and visual analysis

Jiahui Ouyang et al. Heliyon. .

Abstract

Background: The incidence of heart failure, the terminal stage of several cardiovascular diseases, is increasing owing to population growth and aging. Bidirectional crosstalk between the gut and heart plays a significant role in heart failure. This study aimed to analyze the gut-heart axis and heart failure from a bibliometric perspective.

Methods: We extracted literature regarding the gut-heart axis and heart failure from the Web of Science Core Collection database (January 1, 1993, to June 30, 2023) and conducted bibliometric and visualization analyses using Microsoft Excel, CiteSpace, VOSviewer, and the R package "bibliometrix."

Results: The final analysis included 1646 articles with an average of 35.38 citations per article. Despite some fluctuations, the number of articles published per year has steadily increased over the past 31 years, particularly since 2018. A total of 9412 authors from 2287 institutions in 86 countries have contributed to this field. The USA and China have been the most productive countries, with the Cleveland Clinic in the USA and Charité-Universitätsmedizin Berlin in Germany being the most active institutions. The cooperation between countries/regions and institutions was relatively close. Professor Tang WHW was the most productive author in the field and the journal Shocks published the highest number of articles. "Heart failure," "gut microbiota," "trimethylamine N-oxide," and "inflammation" were the most common keywords, representing the current research hotspots. The keyword burst analysis indicated that "gut microbiota" and "short-chain fatty acids" are the current frontier research topics in this field.

Conclusion: Research on the gut-heart axis and heart failure is increasing. This bibliometric analysis indicated that the mechanisms associated with the gut-heart axis and heart failure, particularly the gut microbiota, trimethylamine N-oxide, inflammation, and short-chain fatty acids, will become hotspots and emerging trends in research in this field. These findings provide valuable insights into current research and future directions.

Keywords: Bibliometric analysis; Gut microbiota; Gut-heart axis; Heart failure; Inflammation; Short-chain fatty acids; Trimethylamine N-Oxide.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of the literature screening process.
Fig. 2
Fig. 2
Temporal distribution map of publications and citations. The number of annual publications and citations for the period from 1993 to 2023 are presented.
Fig. 3
Fig. 3
Visualization of countries/regions involved in gut-heart axis and heart failure research. (A) Collaborative network visualization of countries/regions. (B) Geographic distribution and collaboration map of countries/regions.
Fig. 4
Fig. 4
Visualization of authors involved in gut-heart axis and heart failure research. (A) Collaborative network visualization of authors. (B) Collaborative network visualization of co-cited authors.
Fig. 5
Fig. 5
Top 25 references with the strongest citation bursts from 1993 to 2023. Red bars indicate the length of the bursts. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6
Fig. 6
Analysis of keywords in gut-heart axis and heart failure research. (A) Network visualization of keywords. (B) Overlay visualization of keywords. (C) Top 25 keywords with the strongest citation bursts from 1993 to 2023.
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