doi: 10.1038/281114a0.
Fundamental difference between the molecular interactions of agonists and antagonists with the beta-adrenergic receptor
- PMID: 38405
- DOI: 10.1038/281114a0
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Fundamental difference between the molecular interactions of agonists and antagonists with the beta-adrenergic receptor
Nature.
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Abstract
Antagonist binding to the beta-adrenergic receptor is largely entropy driven, with only a small enthalpy component. The binding of agonists, on the other hand, is associated with a large decrease in enthalpy which permits a highly unfavourable decrease in entropy. The thermodynamic differences between the binding of agonists and antagonists may provide new insights into the molecular basis for hormone stimulation of adenylate cyclase activity.
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