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. 2024 Feb 22;7(2):e1923.
doi: 10.1002/hsr2.1923. eCollection 2024 Feb.

Evaluation of the efficacy of a sunscreen containing ultra-long UVA1 and other UVR broad-spectrum filters on skin barrier protection and melanin content reduction in Chinese adults: A single-center study

Xianghua Zhang  1 , Han Tao  2 , Zhongxing Zhang  1 , Wenna Wang  2 , Andrew Steel  2 , Xiaofeng Fang  2 , Xiaofeng He  2
Affiliations

Evaluation of the efficacy of a sunscreen containing ultra-long UVA1 and other UVR broad-spectrum filters on skin barrier protection and melanin content reduction in Chinese adults: A single-center study

Xianghua Zhang et al. Health Sci Rep. .

Abstract

Background and aims: The protection for ultra-long UVA1 is lacked in the market, posing potential damage from ultra-long UVA1 irradiation. The study aims to evaluate the efficacy of a sunscreen containing multiple components, especially Mexoryl® 400 for improving skin barrier function and reducing melanin content.

Methods: This single-center study included adults with sensitive and normal skin in China in November 2022. Participants received the test sunscreen for 4 weeks. Melanin and hemoglobin content, sebum secretion skin hydration, and trans-epidermal water loss were evaluated at T0d, T7d, and T28d. The self-assessment was done at T15min, T7d, and T28d.

Results: Sixty participants were included, including 30 self-claimed sensitive skin in the sunscreen group. The sunscreen demonstrated significant improvements in skin parameters. Skin redness reduced by 9.84% at T28d, sebum content in the forehead area decreased by 22.70% at T28d, and skin stratum corneum hydration increased by 38.44% at T28d, p < 0.001 respectively. Most notably, skin melanin content significantly reduced by 13.49% after 4 weeks' usage (p < 0.001). No adverse reactions were reported in either group.

Conclusions: The study sunscreen improved the skin condition by decreasing the melanin content, regulating skin barrier function, and achieving a balance of skin hydration and sebum secretion.

Keywords: Mexoryl® 400; UVA1; Vitamin E; skin barrier; skin pigmentation.

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Conflict of interest statement

The author(s) are affiliated with L'Oreal (China) and L'Oreal R&I. The remaining author declare no conflict of interest.

Figures

Figure 1
Figure 1
Skin Redness results from T0d to T28d.
Figure 2
Figure 2
Skin sebum content results of forehead area from T0d to T28d.
Figure 3
Figure 3
Skin transepidermal water loss rate results from T0d to T28d.
Figure 4
Figure 4
Skin stratum corneum hydration results from T0d to T28d.
Figure 5
Figure 5
Skin hemoglobin content results from T0d to T28d.
Figure 6
Figure 6
Skin melanin content results from T0d to T28d.
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