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[Preprint]. 2024 Feb 5:rs.3.rs-3911085.
doi: 10.21203/rs.3.rs-3911085/v1.

Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

Lyndsay Harshman  1 , Elliot Stalter, Silvia Verhofste, John Dagle  2 , Emily Steinbach, Patrick Ten Eyck, Linder Wendt, Jeffrey Segar
Affiliations

Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

Lyndsay Harshman et al. Res Sq. .

Update in

Abstract

Objective: Evaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities.

Study design: Retrospective cohort study of infants 260/7-336/7 weeks gestational age (GA) cared for before (2012-15, n = 225) and after (2016-20, n = 157) implementation of the protocol. Within- and between-group changes over time were assessed using repeated measures generalized linear models.

Results: For infants 260/7-296/7 weeks GA, utilization of the protocol was associated with increased mean body weight z-score at 8-weeks postnatal age, increased mean head circumference z-score at 16-weeks postnatal age, and decreased time on mechanical ventilation (all p < 0.02). No impact on growth was identified for infants 30-336/7 weeks GA. Incidences of hypertension, hypernatremia, bronchopulmonary dysplasia, and culture positive sepsis were unaffected by the protocol.

Conclusion: Protocolized Na supplementation results in improved growth and reduced time on invasive mechanical ventilation in extremely preterm infants without increasing incidence of morbidities.

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Conflict of interest statement

Declarations Competing Interests The authors have no competing interests to disclose.

Figures

Figures 1
Figures 1
Flow diagram demonstrating subject enrollment, application of exclusion criteria, and cohort formation.
See this image and copyright information in PMC

References

    1. Al-Dahhan J, Haycock GB, Chantler C, Stimmler L. Sodium homeostasis in term and preterm neonates. I. Renal aspects. Arch Dis Child. 1983;58:335–342. - PMC - PubMed
    1. Gubhaju L, Sutherland MR, Horne RS, Medhurst A, Kent AL, Ramsden A, et al. Assessment of renal functional maturation and injury in preterm neonates during the first month of life. Am J Physiol Renal Physiol. 2014;307:F149–158. - PubMed
    1. Segar JL. Renal adaptive changes and sodium handling in the fetal-to-newborn transition. Semin Fetal Neonatal Med. 2017;22:76–82. - PubMed
    1. Butterworth SA, Lalari V, Dheensaw K. Evaluation of sodium deficit in infants undergoing intestinal surgery. J Pediatr Surg. 2014;49:736–740. - PubMed
    1. Mansour F, Petersen D, De Coppi P, Eaton S. Effect of sodium deficiency on growth of surgical infants: a retrospective observational study. Pediatr Surg Int. 2014;30:1279–1284. - PMC - PubMed

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