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. 2024 Feb 15:53:110188.
doi: 10.1016/j.dib.2024.110188. eCollection 2024 Apr.

Dataset on stroke infarct volume in rodents: A comparison of MRI and histological methods

Rebecca Z Weber  1   2 , Davide Bernardoni  3 , Nora H Rentsch  1   2 , Beatriz Achón Buil  1   2 , Stefanie Halliday  1 , Mark-Aurel Augath  4   5 , Daniel Razansky  4   5 , Christian Tackenberg  1   2 , Ruslan Rust  1   2   6   7
Affiliations

Dataset on stroke infarct volume in rodents: A comparison of MRI and histological methods

Rebecca Z Weber et al. Data Brief. .

Abstract

This dataset offers images of mouse brains impacted by photothrombotic stroke in the sensorimotor cortex published by Weber et al. NeuroImage (2024). Data is gathered using two primary techniques: (1) whole-brain ex-vivo magnetic resonance imaging (MRI) and (2) 40 µm thick coronal histological sections that undergo immunofluorescence staining with NeuroTrace. Infarct areas and volumes are assessed through MRI at two distinct time frames-three days (acute) and 28 days (chronic) following photothrombotic stroke induction. Subsequently, the brains are sectioned into 40 µm thick coronal slices, stained with NeuroTrace, and imaged as whole sections. The dataset holds considerable value for reuse, particularly for researchers focused on stroke volume estimation methods as well as those interested in comparing the efficacy of MRI and histological techniques.

Keywords: Histology; Ischemia; MRI; Preclinical stroke research; Stroke outcome; Stroke volume.

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References

    1. Weber R.Z., et al. A toolkit for stroke infarct volume estimation in rodents. Neuroimage. 2024 doi: 10.1016/j.neuroimage.2024.120518. - DOI - PubMed
    1. Rust R., et al. Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke. Proc. Natl. Acad. Sci. 2019;116(28):14270–14279. doi: 10.1073/pnas.1905309116. - DOI - PMC - PubMed
    1. Rust R., et al. Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability. J. Cereb. Blood Flow Metab. 2023 p. 0271678×231216270 10.1177/0271678×231216270. - PMC - PubMed
    1. Achón Buil B., Rust R. Preserving stroke penumbra by targeting lipid signalling. J. Cereb. Blood Flow Metab. 2023;43(1):167–169. 10.1177/0271678×221121853. - PMC - PubMed
    1. Weber R.Z., Mulders G., Perron P., Tackenberg C., Rust R. Molecular and anatomical roadmap of stroke pathology in immunodeficient mice. Front. Immunol. 2022;13 https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080482 Accessed: Apr. 19, 2023. [Online]. Available: - DOI - PMC - PubMed

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