Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Oct 30;132(2):714-20.
doi: 10.1016/0006-291x(85)91191-x.

Hyaluronic acid synthesis in articular cartilage: an inhibition by hydrogen peroxide

E J Bates, D A Lowther, C C Johnson

Hyaluronic acid synthesis in articular cartilage: an inhibition by hydrogen peroxide

E J Bates et al. Biochem Biophys Res Commun. .

Abstract

The synthesis of hyaluronic acid by bovine articular cartilage in culture was inhibited after treatment with xanthine oxidase and hypoxanthine. Through the use of catalase, superoxide dismutase and the specific iron chelator diethylenetriaminepentaacetic acid, the active species responsible for inhibition was shown to be hydrogen peroxide. Hydrogen peroxide generated by glucose oxidase was also inhibitory. Some recovery of hyaluronic synthesis was evident after a further period of culturing. Proteoglycan synthesis was inhibited in parallel with hyaluronic acid synthesis.

PubMed Disclaimer

Publication types

LinkOut - more resources