Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Nov;86(3):693-5.
doi: 10.1111/j.1476-5381.1985.tb08947.x.

Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo

A Bennett, P B Melhuish, I F Stamford
Comparative Study

Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo

A Bennett et al. Br J Pharmacol. 1985 Nov.

Abstract

Rats were given either carbenoxolone 50 mg kg-1, deglycyrrhized liquorice 1 g kg-1 or vehicle by gastric tube. The doses were repeated 16 h later, and the stomachs removed after another 2 h. The amounts of prostaglandin E (PGE), 6-keto-PGF1 alpha and thromboxane B2, measured by radioimmunoassay in extracts of the gastric corpus and antrum mucosa, were similar in the treated animals and the controls. We conclude that in rats, carbenoxolone and deglycyrrhized liquorice may exert their anti-ulcer effect by a non-prostaglandin mechanism. This contrasts with the mechanism through to occur in man with carbenoxolone.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Physiol. 1973 Mar;229(2):349-60 - PubMed
    1. J Pharm Pharmacol. 1976 Feb;28(2):146-8 - PubMed
    1. Experientia. 1978 Mar 15;34(3):384-5 - PubMed
    1. Scand J Gastroenterol. 1979;14(5):605-7 - PubMed
    1. J Pharm Pharmacol. 1980 Aug;32(8):544-6 - PubMed

Publication types

LinkOut - more resources