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Review
. 2024 Feb 26;206(3):122.
doi: 10.1007/s00203-024-03829-4.

Endophytic fungi as a potential source of anti-cancer drug

Sukanya Sonowal  1   2 , Urvashee Gogoi  1   2 , Kabyashree Buragohain  1   2 , Ratul Nath  3   4
Affiliations
Review

Endophytic fungi as a potential source of anti-cancer drug

Sukanya Sonowal et al. Arch Microbiol. .

Abstract

Endophytes are considered one of the major sources of bioactive compounds used in different aspects of health care including cancer treatment. When colonized, they either synthesize these bioactive compounds as a part of their secondary metabolite production or augment the host plant machinery in synthesising such bioactive compounds. Hence, the study of endophytes has drawn the attention of the scientific community in the last few decades. Among the endophytes, endophytic fungi constitute a major portion of endophytic microbiota. This review deals with a plethora of anti-cancer compounds derived from endophytic fungi, highlighting alkaloids, lignans, terpenes, polyketides, polyphenols, quinones, xanthenes, tetralones, peptides, and spirobisnaphthalenes. Further, this review emphasizes modern methodologies, particularly omics-based techniques, asymmetric dihydroxylation, and biotic elicitors, showcasing the dynamic and evolving landscape of research in this field and describing the potential of endophytic fungi as a source of anticancer drugs in the future.

Keywords: Anticancer drug; Cytotoxicity; Endophytes; Fungus; Microbes.

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References

    1. Abdalla MA, Matasyoh JC (2014) Endophytes as producers of peptides: an overview about the recently discovered peptides from endophytic microbes. Nat Prod Bioprospecting 4(5):257–270. https://doi.org/10.1007/s13659-014-0038-y - DOI
    1. Acuna UM, Shen Q, Ren Y, Lantvit DD, Wittwer JA, Kinghorn AD, Swanson SM, Blanco EJC (2013) Goyazensolide induces apoptosis in cancer cells in vitro and in vivo. Int J Cancer Res 9(2):36–53. https://doi.org/10.3923/ijcr.2013.36.53 - DOI - PubMed - PMC
    1. Adeleke BS, Babalola OO (2021) pharmacological potential of fungal endophytes associated with medicinal plants: a review. J Fungi 7(2):147. https://doi.org/10.3390/jof7020147 - DOI
    1. Adorisio S, Fierabracci A, Muscari I, Liberati AM, Cannarile L, Thuy TT, Sung TV, Sohrab H, Hasan CM, Ayroldi E, Riccardi C, Mazid A, Delfino DV (2019) Fusarubin and anhydrofusarubin isolated from a Cladosporium species inhibit cell growth in human cancer cell lines. Toxins 11(9):503. https://doi.org/10.3390/toxins11090503 - DOI - PubMed - PMC
    1. Adpressa DA, Loesgen S (2016) Bioprospecting chemical diversity and bioactivity in a marine derived Aspergillus terreus. Chem Biodivers 13(2):253–259. https://doi.org/10.1002/cbdv.201500310 - DOI - PubMed

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