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. 2024 Oct 25;69(11):1432-1443.
doi: 10.4187/respcare.11745.

Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation

Harry Ramcharran  1 , Gregory Wetmore  2 , Scott Cooper  3 , Jacob Herrmann  4 , Andrea Fonseca da Cruz  5 , David W Kaczka  6 , Joshua Satalin  1 , Sarah Blair  1 , Penny L Andrews  7 , Nader M Habashi  7 , Gary F Nieman  1 , Michaela Kollisch-Singule  8
Affiliations

Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation

Harry Ramcharran et al. Respir Care. .

Abstract

Backgroud: Lung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [TE]). We hypothesized that expiratory flow would correlate with estimated lung volume (ELV) as measured using a modified nitrogen washout/washin technique in a large-animal lung injury model.

Methods: Eight pigs (35.2 ± 1.0 kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and TE were measured from the expiratory flow profile.

Results: Lung elastance increased with induced lung injury from 29.3 ± 7.3 cm H2O/L to 39.9 ± 15.1cm H2O/L, and chest wall elastance increased with increasing intra-abdominal pressures (IAPs) from 15.3 ± 4.1 cm H2O/L to 25.7 ± 10.0 cm H2O/L in the normal lung and 15.8 ± 6.0 cm H2O/L to 33.0 ± 6.2 cm H2O/L in the injured lung (P = .39). ELV decreased from 1.90 ± 0.83 L in the injured lung to 0.67 ± 0.10 L by increasing IAP to 15 mm Hg. This had a significant correlation with a TE decrease from 2.3 ± 0.8 s to 1.0 ± 0.1 s in the injured group with increasing insufflation pressures (ρ = 0.95) and with the expiratory flow-time slope, which increased from 0.29 ± 0.06 L/s2 to 0.63 ± 0.05 L/s2 (ρ = 0.78).

Conclusions: Changes in ELV over time, and the TE and flow-time slope, could be used to demonstrate evolving lung injury during APRV. Using the slope to infer changes in functional lung volume represents a unique, reproducible, real-time, bedside technique that does not interrupt ventilation and may be used for clinical interpretation.

Keywords: airway pressure release ventilation; end-expiratory lung volume; expiratory flow; time-controlled adaptive ventilation.

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Conflict of interest statement

Dr Kollisch-Singule discloses a relationship with Dräger Medical Systems. Dr Habashi is the founder of ICON, of which Ms Andrews is an employee. Dr Habashi holds patents on a method of initiating, managing, and/or weaning airway pressure release ventilation, as well as controlling a ventilator in accordance with the same. Drs Kaczka and Herrmann are co-founders and shareholders of OscillaVent, and are co-inventors on a patent involving multifrequency oscillatory ventilation. Drs Kaczka and Herrmann disclose a relationship with ZOLL Medical. Dr Kaczka discloses a relationship with Lungpacer Medical. The remaining authors have disclosed no conflicts of interest. The authors maintain that industry had no role in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; nor the preparation, review, or approval of the manuscript.

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References

    1. Puybasset L, Cluzel P, Chao N, Slutsky AS, Coriat P, Rouby JJ. A computed tomography scan assessment of regional lung volume in acute lung injury. The CT Scan ARDS Study Group. Am J Respir Crit Care Med 1998;158(5 Pt 1):1644-1655. - PubMed
    1. Rylander C, Hogman M, Perchiazzi G, Magnusson A, Hedenstierna G. Functional residual capacity and respiratory mechanics as indicators of aeration and collapse in experimental lung injury. Anesth Analg 2004;98(3):782-789. - PubMed
    1. Rahn H, Otis AB, Chadwick LE, Fenn WO. The pressure-volume diagram of the thorax and lung. Am J Physiol 1946;146(2):161-178. - PubMed
    1. Bikker IG, van Bommel J, Reis Miranda D, Bakker J, Gommers D. End-expiratory lung volume during mechanical ventilation: a comparison with reference values and the effect of positive end-expiratory pressure in intensive care unit patients with different lung conditions. Crit Care 2008;12(6):R145. - PMC - PubMed
    1. Bellani G, Guerra L, Musch G, Zanella A, Patroniti N, Mauri T, et al. . Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med 2011;183(9):1193-1199. - PMC - PubMed

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