Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 26;24(1):88.
doi: 10.1186/s12876-024-03177-z.

The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS)

Somaieh Matin  1 , Farahnaz Joukar  2 , Saman Maroufizadeh  3 , Mehrnaz Asgharnezhad  2 , Paridokht Karimian  4 , Fariborz Mansour-Ghanaei  5
Affiliations

The frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among PERSIAN Guilan Cohort Study population (PGCS)

Somaieh Matin et al. BMC Gastroenterol. .

Abstract

Background: This study aimed to investigate the frequency of colorectal lesions in the first-degree relatives of patients with colorectal lesions among the Prospective Epidemiological Research Studies in Iran (PERSIAN )Guilan Cohort Study (PGCS) population.

Methods: In this cross-sectional study, 162 first-degree relatives with a history of colorectal lesions were randomly selected from 52 participants in PGCS. All subjects underwent total colonoscopy by a gastroenterologist, and a pathologist evaluated colorectal biopsies. Also, individuals' demographic information, clinical data, and dietary habits were recorded.

Results: The mean age of the participants was 56.55 ± 7.04. Of 86 colon polyps, 52 neoplastic and 34 non-neoplastic polyps were observed in 56 patients (34.6%). Individuals with age > 60 years had 3.29-fold increased odds of developing colorectal polyps (OR = 3.29, 95% CI: 1.13-9.56, P = 0.029). The smokers were 2.73 times more susceptible to developing colorectal polyps than non-smokers (OR = 2.73, 95% CI: 1.24-6.02, P = 0.013). Moreover, consumption of vegetables more than three times per day was associated with decreased OR of colorectal polyp development (OR = 0.43, CI: 0.19-0.98, P = 0.045).

Conclusions: Considering the high prevalence of neoplastic colorectal polyps among the first-degree relatives of patients with colorectal lesions, early screening is recommended for individuals with a family history of colorectal lesions.

Keywords: Adenomatous polyps; Colorectal lesions; First-degree relatives; Malignancy; Screening.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. C.A. Cancer J Clin. 2020;70(3):145–64. doi: 10.3322/caac.21601. - DOI - PubMed
    1. Sadat KF, Nazemalhosseini ME, Forouzesh F. A quantitative investigation of the bid gene expression in biopsies from colorectal adenomas. Tehran Univ Med J. 2018;76(2):120–8.
    1. Hassan C, Kaminski MF, Repici A. How to ensure patient adherence to colorectal cancer screening and surveillance in your practice. Gastroenterology. 2018;155(2):252–7. doi: 10.1053/j.gastro.2018.06.051. - DOI - PubMed
    1. Mansour-Ghanaei F, Joukar F, Baghaei SM, Yousefi-Mashhoor M, Mohammad R, Naghipour, Sanaei O, et al. Gastric precancerous lesions in first degree relatives of patients with known gastric cancer: a cross-sectional prospective study in Guilan Province, north of Iran. Asian Pac J Cancer Prev. 2012;13(5):1779–82. doi: 10.7314/apjcp.2012.13.5.1779. - DOI - PubMed
    1. Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16(12):713–32. doi: 10.1038/s41575-019-0189-8. - DOI - PubMed