[Modeling and BASIC program for the kinetics of inhalation anesthetic agents]

Abstract

The pharmacokinetics of inhaled anaesthetics has been well described by Eger's model using a monoalveolar lung with continuous alveolar ventilation and four extrapulmonary compartments defined by their blood supply and anaesthetic solubility. The model is presented with its equations. A Basic microcomputer programme is proposed for this model: expected concentrations of anaesthetic in various conditions of administration, ventilation or cardiac output are shown, such as the uptake and distribution of nitrous oxide during anaesthesia. Different inhaled anaesthetics were compared for induction and recovery times in standardized conditions of administration.