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. 2024 May;78(5):1001-1004.
doi: 10.1002/jpn3.12166. Epub 2024 Feb 26.

Equipoise in pediatric acute liver failure

Catherine A Chapin  1 , James E Squires  2 , Simon P Horslen  2 , Estella M Alonso  1
Affiliations

Equipoise in pediatric acute liver failure

Catherine A Chapin et al. J Pediatr Gastroenterol Nutr. 2024 May.
No abstract available

Keywords: corticosteroids; immune dysregulation; immunosuppression; liver transplantation.

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References

REFERENCES

    1. Freedman B. Equipoise and the ethics of clinical research. N Engl J Med. 1987;317:141‐145.
    1. Squires, Jr. RH, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652‐658.
    1. Molina RA, Katzir L, Rhee C, et al. Early evidence of bone marrow dysfunction in children with indeterminate fulminant hepatic failure who ultimately develop aplastic anemia. Am J Transplant. 2004;4:1656‐1661.
    1. Chapin CA, Melin‐Aldana H, Kreiger PA, et al. Activated CD8 t‐cell hepatitis in children with indeterminate acute liver failure: results from a multicenter cohort. J Pediatr Gastroenterol Nutr. 2020;71:713‐719.
    1. Leonis MA, Miethke AG, Fei L, et al. Four biomarkers linked to activation of cluster of differentiation 8‐positive lymphocytes predict clinical outcomes in pediatric acute liver failure. Hepatology. 2021;73:233‐246.

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