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. 2024 Apr;24(4):359-363.
doi: 10.1111/ggi.14840. Epub 2024 Feb 26.

Impact of possible sarcopenia on functional prognosis in patients with acute stroke with premorbid disability

Tomoyuki Ogino  1 , Masafumi Nozoe  2 , Tatsuro Inoue  3 , Mitsuru Ishida  4 , Kenta Yamamoto  4
Affiliations

Impact of possible sarcopenia on functional prognosis in patients with acute stroke with premorbid disability

Tomoyuki Ogino et al. Geriatr Gerontol Int. 2024 Apr.

Abstract

Aim: How possible sarcopenia affects functional prognosis in patients with premorbid disability remains unclear. This study aimed to compare and investigate the impact of possible sarcopenia at admission on functional outcomes at discharge in patients with acute stroke with and without premorbid disability.

Methods: This cohort study enrolled patients who were consecutively admitted to a single center for acute stroke. Calf circumference and grip strength were measured within 7 days of admission, and possible sarcopenia was determined using the Asian Working Group for Sarcopenia 2019 criteria. The Functional Independence Measure (FIM) score at discharge during the acute phase was the primary outcome. To examine the impact of possible sarcopenia on FIM scores at discharge, patients were divided into two groups according to being with or without premorbid disability according to the modified Rankin Scale, and multiple linear regression analysis was performed in each group.

Results: This study included 456 patients with acute stroke (median age, 80 years). In the premorbid-disability group (n = 166), possible sarcopenia was present in 140 patients (84%). Patients without possible sarcopenia had significantly higher FIM scores at discharge compared with those with possible sarcopenia (P < 0.001). However, multiple linear regression analysis showed that possible sarcopenia was not associated with FIM scores at discharge in the premorbid-disability group (β = -0.054, P = 0.346).

Conclusions: The results of this study demonstrated that a high rate of possible sarcopenia was observed in patients with stroke with premorbid disability; however, this did not affect functional prognosis. Geriatr Gerontol Int 2024; 24: 359-363.

Keywords: acute stroke; functional prognosis; possible sarcopenia; premorbid disability.

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References

    1. Cruz‐Jentoft AJ, Sayer AA. Sarcopenia. Lancet 2019; 393: 2636–2646. - PubMed
    1. Kitamura A, Seino S, Abe T et al. Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults. J Cachexia Sarcopenia Muscle 2021; 12: 30–38. - PMC - PubMed
    1. Bunout D, De La Maza MP, Barrera G, Leiva L, Hirsch S. Association between sarcopenia and mortality in healthy older people: sarcopenia and mortality. Australas J Ageing 2011; 30: 89–92. - PubMed
    1. Sato Y, Yoshimura Y, Abe T. Phase angle as an indicator of baseline nutritional status and sarcopenia in acute stroke. J Stroke Cerebrovasc Dis 2022; 31: 106220. - PubMed
    1. Yoshimura Y, Wakabayashi H, Bise T, Tanoue M. Prevalence of sarcopenia and its association with activities of daily living and dysphagia in convalescent rehabilitation ward inpatients. Clin Nutr 2018; 37: 2022–2028. - PubMed