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Comparative Study
. 1985 Aug;31(8):711-20.
doi: 10.1139/m85-135.

Isolation and characterization of a cytolysin produced by Vibrio cholerae serogroup non-O1

B A McCardell, J M Madden, D B Shah
Comparative Study

Isolation and characterization of a cytolysin produced by Vibrio cholerae serogroup non-O1

B A McCardell et al. Can J Microbiol. 1985 Aug.

Abstract

A thermolabile toxin (molecular weight, 52 711; isoelectric point, 8.65) produced by a clinical isolate of Vibrio cholerae serogroup non-O1 was cytotoxic for Y-1 mouse adrenal cells and Chinese hamster ovary cells. The toxin lysed rabbit red blood cells and produced a hemorrhagic zone in rabbit skin. When injected intravenously into adult mice, the cytolysin was rapidly lethal and caused fluid accumulation in both 5- and 18-h rabbit ileal loops. Strains of V. cholerae that produced cytolysin but no cholerae enterotoxin were able to cause fluid accumulation in rabbit intestinal loops.

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