Evaluation of platelet indices as markers of tuberculosis among children in India

Abstract

Children with tuberculosis have increased platelet count and platelet/lymphocyte ratio along with decreased mean platelet volume, suggesting that these indices may be useful as adjunct tools in diagnosis of paediatric tuberculosis https://bit.ly/3Ga4AWT.

FIGURE 1

Participant platelet profiles according to tuberculosis (TB) disease and TB infection status. a) Comparison of platelet (PLT), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) between the three study groups (TB-exposed, tuberculin skin test (TST)-negative (TST−); TB-exposed, TST-positive (TST+) and TB disease (TB+)) of children aged 12–60 months, at three time-points: baseline (week 0), 12 weeks and 24 weeks. b) PLT, MPV and PLR within each study group throughout follow-up. c) Two-way interaction plots showing the average and trend in the observed value of PLT, PLR and MPV over time-points in each study group. Data are adjusted for age, sex and nutritional status. T: time; G: group; TG: interaction of time and group. *: p<0.05; **: p<0.01; ***: p<0.001.